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OBJECTIVE To evaluate the clinical benefit of increasing the osmotic load of the hypertonic solution administered for the treatment of refractory intracranial hypertension episodes in patients with severe head injury. DESIGN Prospective, randomized study. SETTINGS A trauma center in a university hospital. PATIENTS Twenty consecutive patients with head(More)
OBJECTIVE To compare the patterns of evolution of two proinflammatory cytokines (tumor necrosis factor [TNF]-alpha and interleukin-6 [IL-6]) in two major clinical entities associated with systemic inflammatory response: septic shock and multiple trauma (with and without hemorrhagic shock). DESIGN Prospective study of two cohorts of patients. SETTING(More)
BACKGROUND The potential adverse effects of ketamine in neurosurgical anesthesia have been well established and involve increased intracranial pressure (ICP) and cerebral blood flow. However, reexamination of ketamine is warranted because data regarding the effects of ketamine on cerebral hemodynamics are conflicting. METHODS Eight patients with traumatic(More)
OBJECTIVE To determine whether extended use (7 days) would affect the efficiency on heat and water preservation of a hydrophobic condenser humidifier as well as the rate of ventilation-acquired pneumonia, compared with 1 day of use. DESIGN Prospective, controlled, randomized, not blinded, clinical study. SETTING Twelve-bed intensive care unit of a(More)
OBJECTIVE Many heat and moisture exchangers with filter (HMEF) have been developed. In-house data from companies provide some information about their performances; unfortunately, to our knowledge, no comparative evaluation in clinical conditions has been undertaken of these newer products. The aim of this study was to compare the efficiency of two HMEFs,(More)
OBJECTIVE To determine whether changing heat and moisture exchangers every 48 hrs rather than 24 hrs would affect their efficacy to preserve heat and moisture of expiratory gases. DESIGN Prospective, controlled, randomized, not blinded, study. SETTING Intensive care unit of a university hospital. PATIENTS Twenty-nine patients requiring controlled(More)
Cefotetan is a 7-alpha-methoxy beta-lactam. A long serum half-life and resistance to beta-lactamase hydrolysis have made cefotetan an attractive chemotherapeutic agent, and the results of clinical trials worldwide have demonstrated its efficacy in a wide variety of clinical situations. Cefotetan can be administered intravenously (bolus or infusion) or(More)
The objective of the current study is to compare the use of a nasal continuous positive airway pressure (nCPAP) to a high-flow humidified nasal cannula (HFNC) in infants with acute bronchiolitis, who were admitted to a pediatric intensive care unit (PICU) during two consecutive seasons. We retrospectively reviewed the medical records of all infants admitted(More)
OBJECTIVE Regional guideline for immediate tracheal suctioning (ITS) in vigorous and non-vigorous infants born through meconium-stained amniotic fluid (MSAF) has been established in 2003. The objective of this study was to evaluate guideline application. STUDY DESIGN Prospective cohort. PATIENTS AND METHODS The first part of the study was a short survey(More)