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Phenotypic differences among mice with disrupted genes and those with wild-type alleles have not provided the necessary evidence for desired gene/phenotype correlations. These differences could be due to "passenger genes" from the donor 129 strains that are used to produce stem cells. Three variations of attack behavior were measured, using mice carrying a(More)
Intraperitoneal injection of adult male mice with the neuroactive steroid dehydroepiandrosterone sulfate (DHEAS) at 1 and 40 mg/kg caused dose-dependent increases in the concentration of both this compound and its corresponding free steroid DHEA in brain within 1 h of injection. Pretreatment of these animals for 24 h with the steroid sulfatase inhibitor(More)
The steroid sulfatase enzyme (STS) regulates the formation of dehydroepiandrosterone (DHEA) from dehydroepiandrosterone-sulfate (DHEAS). DHEAS is a well-known negative allosteric modulator of the GABA(A) receptor-gated chloride channels. It is classified as an excitatory neurosteroid. The implication of GABA(A) receptor activity in aggressive behavior in(More)
For modern Diesel engines, accurate fuel-air ratio AFR and Exhaust Gas Recirculation (EGR) rates control is important for manufacturers to face a more restrictive legislation levels. To fulfill the requirements, hardware devices such (EGR) and Variable Geometry Turbochargers (VGT) valves have been introduced, and sophisticated control algorithms were(More)
STS is the single enzyme that converts all steroid sulfates into their free steroid forms. Initiation of attack behavior against conspecific male mice appeared to be linked to Sts. Here we have confirmed the role of Sts through an association study with attack behavior. Previous studies indicated a positive correlation between the initiation of attack(More)
A finite element method is presented to compute time harmonic microwave fields in three dimensional configurations. Nodal-based finite elements have been coupled with an absorbing boundary condition to solve open boundary problems. This paper describes how the modeling of large devices has been made possible using parallel computation. New algorithms are(More)
This paper deals with a concurrent version of the finite element time domain method. The algorithm works in SPMD mode and is executed in the MPI distributed environment. Its properties are validated with some different multi-computer, loosely coupled platforms. The real value and approximated asymptotic values of the basic metrics of speedup are presented(More)