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A high-throughput protein refolding screen in 96-well format combined with design of experiments to optimize the refolding conditions.
- Vincent Dechavanne, Nicolas Barrillat, +5 authors Laurent Chevalet
- Chemistry, Medicine
- Protein expression and purification
- 1 February 2011
Production of correctly folded and biologically active proteins in Escherichiacoli can be a challenging process. Frequently, proteins are recovered as insoluble inclusion bodies and need to be… Expand
Demonstration of physicochemical and functional similarity between the proposed biosimilar adalimumab MSB11022 and Humira®
ABSTRACT Biosimilars are biological products that are highly similar to existing products approved by health authorities. Demonstration of similarity starts with the comprehensive analysis of the… Expand