Laurent Le Guillou

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Tissue mechanics have been shown to play a key role in the regulation of morphogenesis in animals [1-4] and may have an equally important role in plants [5-9]. The aerial organs of plants are formed at the shoot apical meristem following a specific phyllotactic pattern [10]. The initiation of an organ from the meristem requires a highly localized(More)
Aims. We present cosmological constraints from a joint analysis of type Ia supernova (SN Ia) observations obtained by the SDSS-II and SNLS collaborations. The data set includes several low-redshift samples (z < 0.1), all three seasons from the SDSS-II (0.05 < z < 0.4), and three years from SNLS (0.2 < z < 1), and it totals 740 spectroscopically confirmed(More)
Y.R. Rahal1 , C. Afonso2 , J.-N. Albert1, J. Andersen3, R. Ansari1, É. Aubourg2 , P. Bareyre2, J.-P. Beaulieu4, X. Charlot2, F. Couchot1, C. Coutures2,4, F. Derue1†, R. Ferlet4, P. Fouqué7,8, J.-F. Glicenstein2, B. Goldman2‡, A. Gould5, D. Graff5§, M. Gros2, J. Haı̈ssinski1, C. Hamadache2¶, J. de Kat2, É. Lesquoy2,4, C. Loup4, L. Le Guillou2‖, C.(More)
Using a segment strategy, we have synthesized four iodinated photoactivatable cyclic peptidic ligands of oxytocin, bearing a beta-mercapto-betabeta-cyclopentamethylene propionic group (Pmp) on their N-terminus. All the syntheses were RP-HPLC monitored, and the compounds were HPLC purified. They were characterized by 1H NMR, MALDI-TOF, or FAB mass(More)
We present a new EROS-2 measurement of the microlensing optical depth toward the Galactic Bulge. Light curves of 5.6 × 106 clump-giant stars distributed over 66 deg2 of the Bulge were monitored during seven Bulge seasons. 120 events were found with apparent amplifications greater than 1.6 and Einstein radius crossing times in the range 5 d < tE < 400 d.(More)
Five years of eros data towards the Small Magellanic Cloud have been searched for gravitational microlensing events, using a new, more accurate method to assess the impact of stellar blending on the efficiency. Four long-duration candidates have been found which, if they are microlensing events, hint at a non-halo population of lenses. Combined with results(More)
The early development of the mammalian embryo leads to the formation of a structure composed by an outer layer of polarized cells surrounding an inner mass of non-polarized cells. Experimental biology has shown that this organisation results from changes in cell polarity, cell shape and intercellular contacts at the 8 and 16cell stages. In order to examine(More)
To study the vasopressin receptor domains involved in the hormonal binding, we synthesized natural and modified fragments of V1a vasopressin receptor and tested their abilities to affect hormone-receptor interactions. Natural fragments mimicking the external loops one, two, and three were able to inhibit specific vasopressin binding to V1a receptor. In(More)
The isomerization of all-trans retinol (vitamin A) to 11-cis retinol in the retinal pigment epithelium (RPE) is a key step in the visual process for the regeneration of the visual pigment chromophore, 11-cis retinal. LRAT and RPE65 are recognized as the minimal isomerase catalytic components. However, regulators of this rate-limiting step are not fully(More)
We searched for an optical counterpart to the first gravitational-wave source discovered by LIGO (GW150914), using a combination of the Pan-STARRS1 wide-field telescope and the Public ESO Spectroscopic Survey of Transient Objects (PESSTO) spectroscopic follow-up programme. As the final LIGO sky maps changed during analysis, the total probability of the(More)