Laurent Le Cam

Matthieu Lacroix4
Elodie Hatchi3
Claude Sardet3
Olivier Kirsh2
4Matthieu Lacroix
3Elodie Hatchi
3Claude Sardet
2Olivier Kirsh
Learn More
  • Laurent Le Cam, Laëtitia K. Linares, Conception Paul, Eric Julien, Matthieu Lacroix, Elodie Hatchi +6 others
  • 2006
p53 is regulated by multiple posttranslational modifications, including Hdm2-mediated ubiquitylation that drives its proteasomal degradation. Here, we identify the p53-associated factor E4F1, a ubiquitously expressed zinc-finger protein first identified as a cellular target of the viral oncoprotein E1A, as an atypical ubiquitin E3 ligase for p53 that(More)
—Gate length variability is the dominant cause of performance variability in nanometer IC technologies. In this work, layout design techniques for reducing gate length variability are presented. It involves making choices in the layout design that improve the dimensional control of the lithographic process. By relaxing the minimum pitch and by reducing the(More)
Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with impaired differentiation programs caused by recurrent mutations, such as the isocitrate dehydrogenase (IDH) mutations found in 15% of AML patients. These mutations result in the production of the oncometabolite (R)-2-hydroxyglutarate (2-HG), leading to a(More)
Regeneration relies on coordinated action of multiple cell types to reconstitute the damaged tissue. Here we inactivate the endocytic adaptor protein Numb in skeletal muscle stem cells prior to chronic or severe muscle injury in mice. We observe two types of senescence in regenerating muscle; a transient senescence in non-myogenic cells of control and Numb(More)
The multifunctional E4F1 protein was originally discovered as a target of the E1A viral oncoprotein. Growing evidence indicates that E4F1 is involved in key signaling pathways commonly deregulated during cell transformation. In this study, we investigate the influence of E4F1 on tumorigenesis. Wild-type mice injected with fetal liver cells from mice lacking(More)
  • Geneviève Rodier, Olivier Kirsh, Martín Baraibar, Thibault Houlès, Matthieu Lacroix, Hélène Delpech +9 others
  • 2015
Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an intriguing capacity to simultaneously regulate metabolism and cell cycle. Here, we show that another factor, the multifunctional protein E4F1, directly controls genes involved in mitochondria functions and(More)
  • 1