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To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens.(More)
BACKGROUND Transcription regulatory networks are composed of protein-DNA interactions between transcription factors and their target genes. A long-term goal in genome biology is to map protein-DNA interaction networks of all regulatory regions in a genome of interest. Both transcription factor -and gene-centered methods can be used to systematically(More)
Large collections of protein-encoding open reading frames (ORFs) established in a versatile recombination-based cloning system have been instrumental to study protein functions in high-throughput assays. Such 'ORFeome' resources have been developed for several organisms but in virology, plasmid collections covering a significant fraction of the virosphere(More)
  • N B T M Lahn, K Pearson, Jegalian, P J Wang, J R Mccarrey, F Yang +62 others
  • 2004
presence of these two patterns in both humans and mouse suggests their importance in the evolution of mammalian X chromosomes. Our sample of functional retroposed genes in the mammalian genomes is likely at least an order of magnitude smaller than the actual number (10, 11). Notably, our analyses exclude retrocopies maintaining introns, such as partially(More)
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