Laurent Gouthière

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The choice of the period is a problematic in the field of the analysis of rhythms which is not yet sufficiently formalized in the sense that it was often postulated that the period is known and more precisely in the case of the circadian rhythms. We propose some methods which have a great reliability in the determination of the period and consequently can(More)
Clinical and experimental observations indicate that resistance to anticancer drugs may be spontaneously reversible over time, but the mechanisms of this reversal are unknown. The resistance of cultured hepatoma cells to methotrexate (MTX) and cisplatin was followed for 9 months. Cells were exposed to three treatments: MTX 200 nM for 24 h or 15 nM(More)
The aim of this study was to show the resistance and persistence of the circadian rhythm of temperature (T degree) and the sleep quality of athletic subjects and sedentary subjects engaged in night work, and attempt to explain the mechanisms that influence these differences. The effects of night work on biological rhythms have been studied extensively in(More)
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