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Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells.
Glycosylation is one of the most common posttranslational modifications of proteins. It has important roles for protein structure, stability and functions. In vivo the glycostructures influenceExpand
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A high-throughput protein refolding screen in 96-well format combined with design of experiments to optimize the refolding conditions.
Production of correctly folded and biologically active proteins in Escherichiacoli can be a challenging process. Frequently, proteins are recovered as insoluble inclusion bodies and need to beExpand
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Design of Experiment in CHO and HEK transient transfection condition optimization.
Transient gene expression (TGE) is a well-established enabling technology for rapid generation of recombinant proteins, with Human Embryonic Kidney (HEK) and Chinese Hamster Ovary (CHO) cell linesExpand
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Demonstration of physicochemical and functional similarity between the proposed biosimilar adalimumab MSB11022 and Humira®
ABSTRACT Biosimilars are biological products that are highly similar to existing products approved by health authorities. Demonstration of similarity starts with the comprehensive analysis of theExpand
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In vivo processing of CXCL12α/SDF‐1α after intravenous and subcutaneous administration to mice
CXCL12α has been shown to be selectively processed at the N‐ and C‐termini in blood and plasma in vitro. In order to study the processing in vivo, several versions of CXCL12α were expressed andExpand
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