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Gert Van Assche, Axel Dignass, Julian Panes, Laurent Beaugerie, John Karagiannis, Mathieu Allez, Thomas Ochsenkühn, Tim Orchard, Gerhard Rogler, Edouard Louis, Limas Kupcinskas, Gerassimos Mantzaris, Simon Travis, Eduard Stange for the European Crohn's and Colitis Organisation (ECCO) University Hospital Gasthuisberg, Leuven, Belgium Markus Krankenhaus,(More)
BACKGROUND The intestinal microbiota is suspected to play a role in colitis and particularly in inflammatory bowel disease (IBD) pathogenesis. The aim was to compare the fecal microbiota composition of patients with colitis to that of healthy subjects (HS). METHODS fecal samples from 22 active Crohn's disease (A-CD) patients, 10 CD patients in remission(More)
BACKGROUND & AIMS Early intensive therapy in Crohn's disease should be considered only in patients with disabling disease. The aim of our study was to identify at diagnosis factors predictive of a subsequent 5-year disabling course. METHODS Among the 1526 patients seen at our unit with Crohn's disease diagnosed between 1985 and 1998, we excluded patients(More)
BACKGROUND The Vienna classification of Crohn's disease (CD) distinguishes three patient subgroups according to disease behavior: stricturing, penetrating, and inflammatory. Our aim was to assess the long-term evolution of the disease behavior of CD and to determine the predictive factors and prognostic implications of this evolution. METHODS Occurrence(More)
BACKGROUND AND AIMS To evaluate the benefit of smoking cessation in individuals with Crohn's disease, we performed an intervention study in a large cohort of smokers with the disease. METHODS Repeated counseling to stop smoking, with easy access to a smoking cessation program, was given to 474 consecutive smokers with Crohn's disease. Patients who stopped(More)
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 3: Special situations Gert Van Assche⁎, Axel Dignass⁎⁎, Bernd Bokemeyer, Silvio Danese, Paolo Gionchetti, Gabriele Moser, Laurent Beaugerie, Fernando Gomollón, Winfried Häuser, Klaus Herrlinger, Bas Oldenburg, Julian Panes, Francisco Portela, Gerhard Rogler,(More)
BACKGROUND & AIMS Patients with inflammatory bowel disease (IBD) who have been exposed to thiopurines might have an increased risk of skin cancer. We assessed this risk among patients in France. METHODS We performed a prospective observational cohort study of 19,486 patients with IBD, enrolled from May 2004 to June 2005, who were followed up until(More)
BACKGROUND AND AIMS Obesity is unusual in Crohn's disease and the particularities of the disease in obese patients have not been studied. METHODS 2065 patients were studied retrospectively. Obesity was defined by a BMI value >25.0 at disease onset and >30.0 at any time during the course of the disease. Disease characteristics, therapeutic needs, and(More)
OBJECTIVE Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response. DESIGN Faecal and serum BA rates, expressed as a proportion of total BA, were assessed by(More)