Laurent Beaugerie

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The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis Gert Van Assche⁎, Axel Dignass⁎, Julian Panes, Laurent Beaugerie, John Karagiannis, Mathieu Allez, Thomas Ochsenkühn, Tim Orchard, Gerhard Rogler, Edouard Louis, Limas Kupcinskas, Gerassimos Mantzaris, Simon Travis, Eduard Stange for(More)
BACKGROUND & AIMS Adherent-invasive Escherichia coli (AIEC) pathovar has been identified in the intestinal mucosa of patients with Crohn's disease (CD). AIEC reference strain LF82 is able to adhere to intestinal epithelial cells, to invade epithelial cells via a mechanism involving actin polymerization and microtubules, and to survive and replicate within(More)
BACKGROUND The intestinal microbiota is suspected to play a role in colitis and particularly in inflammatory bowel disease (IBD) pathogenesis. The aim was to compare the fecal microbiota composition of patients with colitis to that of healthy subjects (HS). METHODS fecal samples from 22 active Crohn's disease (A-CD) patients, 10 CD patients in remission(More)
BACKGROUND The Vienna classification of Crohn's disease (CD) distinguishes three patient subgroups according to disease behavior: stricturing, penetrating, and inflammatory. Our aim was to assess the long-term evolution of the disease behavior of CD and to determine the predictive factors and prognostic implications of this evolution. METHODS Occurrence(More)
BACKGROUND Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study. METHODS 19,486 patients with inflammatory bowel disease, of whom 11,759 (60.3%) had Crohn's disease and 7727 (39.7%) had ulcerative(More)
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 3: Special situations Gert Van Assche⁎, Axel Dignass⁎⁎, Bernd Bokemeyer, Silvio Danese, Paolo Gionchetti, Gabriele Moser, Laurent Beaugerie, Fernando Gomollón, Winfried Häuser, Klaus Herrlinger, Bas Oldenburg, Julian Panes, Francisco Portela, Gerhard Rogler,(More)
BACKGROUND & AIMS Early intensive therapy in Crohn's disease should be considered only in patients with disabling disease. The aim of our study was to identify at diagnosis factors predictive of a subsequent 5-year disabling course. METHODS Among the 1526 patients seen at our unit with Crohn's disease diagnosed between 1985 and 1998, we excluded patients(More)
BACKGROUND/AIM Immunosuppressants are now used much earlier in the course of Crohn's disease; however their effect on the natural history of the disease, especially on the need for surgery, is not known. The aim of this study was to assess the evolution of the need for surgery in Crohn's disease during the last 25 years. PATIENTS AND METHODS The medical(More)
OBJECTIVE Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response. DESIGN Faecal and serum BA rates, expressed as a proportion of total BA, were assessed by(More)
BACKGROUND & AIMS Patients with inflammatory bowel disease (IBD) who have been exposed to thiopurines might have an increased risk of skin cancer. We assessed this risk among patients in France. METHODS We performed a prospective observational cohort study of 19,486 patients with IBD, enrolled from May 2004 to June 2005, who were followed up until(More)