Laurens H. Smith

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Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large interpatient variability, partly due to genetic variations in the gene encoding cytochrome P450 (CYP)2C9 (CYP2C9). Furthermore, the variant allele HLA-B*15:02, encoding human leukocyte antigen, is associated with an increased risk of Stevens-Johnson syndrome and toxic(More)
Bovine tuberculosis (Mycobacterium bovis) was discovered in northern Michigan white-tailed deer (Odocoileus virginianus) in 1994, and has been known to exist in Michigan cattle herds since 1998. Despite efforts to eradicate the disease in cattle, infection and re-infection of farms continues to occur, suggesting transmission among cattle, deer, or other(More)
A method for measuring urea production by isolated erythrocytes and leucocytes under physiologic conditions is described. Erythrocytes from 10 normal subjects formed an average of 82.5 mmoles urea/mi. packed cells/hr. Leucocytes formed 7.4 mmoles urea/108 cells/hr. By extrapolation, total urea synthesis by circulating erythrocytes would be approximately 270(More)
2005 iii This thesis is dedicated to my parents, for having faith in me. Their love, support and encouragement, even from across the world, has been a never-ending source of inspiration. This thesis focuses on an intuitive approach to natural scene segmentation. This research uses color and texture features in cooperation to provide comprehensive knowledge(More)
The phylogenetic structure of ferns (5 monilophytes) is explored here, with a special focus on the early divergences among leptosporangiate lineages. Despite considerable progress in our understanding of fern relationships, a rigorous and comprehensive analysis of the early leptosporangiate divergences was lacking. Therefore, a data set was designed here to(More)
Blastomyces dermatitidis, a pathogenic fungal organism, is able to exist in two different morphologies, a multicellular mycelium or a unicellular yeast,according to temperature, 25°C and 37°C respectively. The switching between morphologies must be accompanied by a cascade of signaling events in which expression of genes responsible for the change of(More)
Because excretion of certain nucleosides increases in all types of cancer, detection and treatment of the disease would be enhanced by rapid, simple quantitation of such nucleotides. To facilitate these analyses in urine, we have prepared a specific adsorbent for nucleosides. The affinity adsorbent gel contains an immobilized phenylboronic acid group that(More)
Evaluating the Effectiveness of a Telepresence-Enabled Cognitive Apprenticeship Model of Teacher Professional Development by R. Shawn Edmondson, Doctor of Philosophy Utah State University, 2005 Major Professor: Dr. Steve Lehman Department: Psychology, Research and Evaluation Methodology This exploratory research used a mixed-methods design to compare the(More)
This article describes the development of a holistic admission assessment for all inpatients admitted to a 66-bedded hospice, structured in the form of an integrated care pathway (ICP). The need for an improved assessment process was identified by clinical staff, who recognized that the existing assessment was not truly holistic and was dependent on the(More)
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