Laurence Weiss

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BACKGROUND The main purpose of our study was to define an animal model of vagal hyperreactivity and its genetic transmission. METHODS AND RESULTS We first investigated the vagal reactivity with phenylephrine in conscious rabbits. Barosensitivity and the maximal bradycardic response were measured at the upper mean blood pressure plateau. Hyperreactive (H)(More)
Omalizumab was shown to reduce exacerbation rate in moderate to severe allergic asthma. Objective: To evaluate omalizumab efficacy and safety in a real life setting in severe asthmatic children. Methods: 104 children (6-18y), followed-up in paediatric pulmonary tertiary care centres were included at omalizumab onset. Asthma control levels, exacerbations,(More)
OBJECTIVE To report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome. METHODS In 2014, data on survival, kidney function, 24 h proteinuria,(More)
We previously reported the French real-life experience of 1 year of add-on treatment with omalizumab in 101 severe allergic asthmatic children (6–18 years), 92 of whom were still receiving the treatment at the end of the first year [1]. The study provided complementary data to the previous randomised trials [2–6]. We showed a marked drop of 72% in the mean(More)
BACKGROUND Although an early decrease in proteinuria has been correlated with good long-term renal outcome in lupus nephritis (LN), studies aimed at defining a cut-off proteinuria value are missing, except a recent analysis performed on patients randomised in the Euro-Lupus Nephritis Trial, demonstrating that a target value of 0.8 g/day at month 12(More)
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