Laurence Molina

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Diabetic nephropathy (DN) develops in a large number of type 1 (T1D) and type 2 diabetic (T2D) patients after a variable latency period. DN absolute number is increasing because of greater longevity and the epidemic of diabetes [1]. Although this disease is progressively becoming a heavier burden for the health care system, it is as yet poorly understood in(More)
Before acquiring their mature state, cochlear hair cells undergo a series of changes in expression of ion channels. How this complex mechanism is achieved is not fully understood. Tmprss3, a type II serine protease expressed in hair cells, is required for their proper functioning at the onset of hearing. To unravel the role of Tmprss3 in the acquisition of(More)
BACKGROUND In current comparative proteomics studies, the large number of images generated by 2D gels is currently compared using spot matching algorithms. Unfortunately, differences in gel migration and sample variability make efficient spot alignment very difficult to obtain, and, as consequence most of the software alignments return noisy gel matching(More)
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