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We present a determination of the optical QSO luminosity function and its cos-mological evolution with redshift for a sample of over 6000 QSOs identified primarily from the first observations of the 2dF QSO Redshift Survey (2QZ). For QSOs with −26 < M B < −23 and 0.35 < z < 2.3, we find that pure luminosity evolution (PLE) models provide an acceptable fit(More)
The net effect of µ-opioid receptor agonists on intracranial self-stimulation (ICSS) in rats reflects an integration of rate-increasing and rate-decreasing effects. Previous opioid exposure is associated with tolerance to rate-decreasing effects and the augmented expression of abuse-related rate-increasing effects. This finding was replicated here with(More)
This study explored the relationships in man between various pharmacological effect of delta 9-tetrahydrocannabinol (THC), plasma THC concentration, and pharmacokinetic parameters of THC. Three male and three female experienced marihuana users smoked two standard marihuana cigarettes. The relationships between heart rate, subjective "high" rating, Linear(More)
RATIONALE Pharmacological manipulations of the type 1 cannabinoid receptor (CB1) suggest a role for CB1 in morphine-induced antinociception, but studies utilizing CB1 knockout (KO) mice do not support this conclusion. Since studies using CB1 KO mice to study morphine's antinociceptive effects have only examined thermal nociception, this study examines these(More)
Nine groups of rats (n = 6 per group) were adapted to a daily one-half hour period of water availability. When intake had stabilized, they were allowed access to a 0.1% (w/v) solution of saccharin, and immediately afterward were given IP injections of isotonic saline; bupropion HCl (10.0, 20.0, or 40.0 mg/kg); d-amphetamine-sulfate (0.5, 1.0, 2.0 mg/kg); or(More)
We are currently carrying out a major redshift survey of 30000 QSOs using the 2dF facility on the Anglo-Australian Telecope. As of January 1998, over 1000 QSO redshifts have been obtained for the survey, making this the largest single homogeneous sample of QSOs yet compiled. When complete the survey will be used to provide important information on the(More)
We present a catalogue comprising over 10000 QSOs covering an effective area of 289.6 deg 2 , based on spectroscopic observations with the 2-degree Field instrument at the Anglo-Australian Telescope. This catalogue forms the first release of the 2-degree Field QSO Redshift Survey. QSO candidates with 18.25 < b J < 20.85 were obtained from a single(More)
Male golden hamsters (Mesocricetus auratus) were examined from 3 to 9 wk of age for morphological, physiological, and behavioral indices of sexual maturation. Although each of the eight variables selected for measurement displayed a unique developmental profile, a principal-components analysis of these variables resulted in the extraction of two principal(More)
The role of genetic factors in determining risk for status epilepticus (SE) was examined in twins identified using the population-based Virginia Twin Registry. Concordance rates for SE were 0.38 for monozygotic (MZ) and 0.00 for dizygotic (DZ) twins, with the rate in MZs being significantly increased over DZs. The prevalence of SE in MZ co-twins of affected(More)
The purpose of this study was to examine the roles of genetic and environmental factors in the etiology of epilepsy and seizures in twins ascertained from the Virginia Twin Registry. Health history information on twins was collected by questionnaire. Concordance rates were calculated and used to estimate degree of concordance for seizure types in(More)