Laurence Halimi

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BACKGROUND Adherence in severe asthma is a difficult health problem. Although psychosocial factors may be responsible for non-adherence, few longitudinal studies have investigated their link with adherence, with most studies having focused on pharmacology. METHODS Sixty patients with severe asthma were recruited. Adherence was electronically monitored(More)
The landscape of asthma has considerably changed after 40 years of inhaled corticosteroid development and nearly 20 years since the first monoclonal antibodies (mAbs) were approved. New members of pharmacological families and more effective drug-delivery devices have been designed but the proportion of uncontrolled patients, unfortunately, remains stable.(More)
This study is designed to review 10 years' experience with the use of american injectable collagens (Zyderm I, Zyderm II, Zyplast) in the field of plastic surgery. After reviewing the characteristics of the product and its immunological aspects, the general principles of use are recalled: preliminary advice, contraindications and precautions, injection(More)
Adherence in asthma is an important cause for concern. Although nearly 50% of asthma patients are considered poorly adherent to therapeutic advices, adherence is still difficult to assess, understand and improve despite major medical consequences. In this review, we revisited the literature of the last 10 years related to adherence in severe asthma. The(More)
Difficult asthma is a major issue in pulmonary medicine today because of its cost for patients and society. Difficult asthma is asthma that remains uncontrolled despite optimal specialist management. The validity of the diagnosis must be reconsidered in these cases: associated or differential diagnoses may be involved in the lack of control, and it is(More)
BACKGROUND Most patients with asthma can be controlled with suitable medication, but 5-10% of them remain difficult to control despite optimal management. OBJECTIVE We investigated whether patients with difficult-to-control asthma (DCA) or controlled asthma (CA) differ with respect to psychological factors, such as general control beliefs on life events.(More)
P atient education is based on a delicate balance between a suffering individual and a clinician. This professional is supposed to assume a public service duty falling between institutional requirements and the choices of patients. This task is complicated by one indisputable fact: it is impossible to make people do what one wants them to do. In this(More)
BACKGROUND Reasons for asthma hospitalizations are dynamic and complex. Comorbid conditions are important contributors to most chronic diseases today. We aim to characterize and describe risk factors associated with hospitalizations due to asthma in the Languedoc-Roussillon region (France) in 2009. METHODS Programme de Médicalisation des Systèmes(More)
Randomized studies show that the best results come from patient-focused educational programs based on self-management (written and individualized action plan, self-monitoring, and regular medical review). The simple provision of information about asthma does not improve health outcomes. Teenagers with asthma are the most fragile patients, because of the(More)
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