Laurence Foix-l'Hélias

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BACKGROUND Antenatal glucocorticoid therapy decreases the incidence of several complications among very premature infants. However, its effect on the occurrence of cystic periventricular leukomalacia, a major cause of cerebral palsy, remains unknown. METHODS We retrospectively analyzed a cohort of 883 live-born infants, with gestational ages ranging from(More)
Because of the important changes in medical care and the social context of pregnancy, the relevance of well-established risk factors of preterm delivery (< 37 weeks) needs to be re-assessed. The objective of this study was to determine whether the associations between maternal characteristics and preterm delivery in France in 1995 were similar to those in(More)
PURPOSE Urinary tract infection leads to a diagnosis of moderate or high grade (III or higher) vesicoureteral reflux in approximately 15% of children. Predicting reflux grade III or higher would make it possible to restrict cystography to high risk cases. We aimed to derive a clinical decision rule to predict vesicoureteral reflux grade III or higher in(More)
BACKGROUND Retinoblastoma (RB) is the most frequent eye tumour in children, with an incidence of 1 in 15-20,000 births. It accounts for 11% of all cancers in the first year of life. Except for the hereditary forms, its causes are not well-known. Studies have recently suggested an increased risk of RB among children born after IVF, but the relevant(More)
IMPORTANCE Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. OBJECTIVES To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and(More)
Complex chromosome translocations involve changes between three or more chromosomes and are found very rarely in the general population. 2 Abnormal phenotype, mental retardation, recurrent miscarriages, and infertility have been reported in carriers of apparently balanced complex chromosomal rearrangements. Phenotypic abnormalities in patients with(More)
OBJECTIVE To evaluate the rates of in-hospital death, neonatal complications, and 5-year outcomes of infants born at 30-34 weeks of gestation. METHODS In nine regions of France, all 2,020 stillbirths and live births at 30, 31, and 32 weeks in 1997 and all 457 births at 33 and 34 weeks in April and October 1997 were recorded. Survivors were evaluated at 5(More)
OBJECTIVE To validate high serum procalcitonin (PCT) as a predictor of vesicoureteral reflux (VUR) in children with a first febrile urinary tract infection (UTI). STUDY DESIGN This secondary analysis of prospective hospital-based cohort studies included children ages 1 month to 4 years with a first febrile UTI. RESULTS Of the 398 patients included in 8(More)
OBJECTIVE To analyse the delivery room management of babies born between 22 and 26 weeks of completed gestational age and to identify the factors associated with the withholding or withdrawal of intensive care. STUDY DESIGN Population-based cohort study. PATIENTS AND METHODS Our study population comprised 2145 births between 22 and 26 completed weeks(More)
OBJECTIVE Many extremely preterm neonates die in the delivery room (DR) after decisions to withhold or withdraw life-sustaining treatments or after failed resuscitation. Specific palliative care is then recommended but sparse data exist about the actual management of these dying babies. The objective of this study was to describe the clinical course and(More)