Laurence E. Dahners

Learn More
Fractures of the proximal humerus are common, especially in elderly individuals, and are usually classified according to Neer into fractures having one, two, three, or four parts with or without an associated dislocation or an injury splitting the humeral head. This article is intended to assist the surgeon in selecting and using techniques for internal(More)
BACKGROUND Prophylactic systemic antibiotics significantly lower the risk of postoperative infection, and injection of antibiotics directly into the wound cavity has been found to be even more effective. In this study, we investigated the efficacy of direct injection of antibiotics into a wound cavity after wound closure, both alone and in combination with(More)
In previous studies, platelet-derived growth factor has demonstrated beneficial in vivo effects on wound healing. We report the results of two studies of platelet-derived growth factor in the rat medial collateral ligament injury model. Experimental injury sites were implanted with platelet-derived growth factor, whereas contralateral controls received only(More)
Platelet-derived growth factor, basic fibroblast growth factor, and insulin-like growth factor Type 1 have demonstrated chemotactic and mitogenic properties in vitro that could benefit healing ligaments. These growth factors also have demonstrated in vivo effects when used in skin wound-healing models. In a previous study, bFGF and IGF-1, used alone, failed(More)
UNLABELLED Early surgical management of femoral shaft fracture (FSF) is considered the standard but patients are still treated nonsurgically. The purpose of this study was to analyze the results of management of FSF in a large population based data base. METHODS Data were obtained from a statewide hospital discharge data base for 1989-1992. Adults having(More)
Although the precise etiology of low back pain is disputed, degeneration of the intervertebral disc is believed to play an important role. Many animal models have been described which reproduce the changes found in degenerative disc disease, but none allow for efficient, large-scale testing of purported therapeutic agents. The purpose of this study was to(More)
OBJECTIVE To assess the viability of using a modified flexible suture implant instead of a tricortical screw for fixation of ankle syndesmosis failures. DESIGN Randomized biomechanical study. SETTING Orthopaedic Research Laboratories at the University of North Carolina at Chapel Hill. INTERVENTION Formalin-preserved cadaveric legs were used in pairs.(More)
The effect of cefazolin and vancomycin on osteoblast-like cells was studied. Cells from the MG-63 human osteosarcoma cell line were grown in antibiotic free media and exposed to concentrations of cefazolin and vancomycin at order of magnitude intervals between 0 and 10,000 microg/ml. For cefazolin, a second interval was performed between 100 and 1000(More)
Biomechanical testing of an experimental pelvic external fixation frame incorporating a large tubular horizontal member was carried out on formalin-fixed cadaver pelves with simulated vertical shear injuries. The device was tested with 5 mm standard and 6 mm experimental pins, and was compared to a Pittsburgh triangular (PT) frame constructed of standard(More)
OBJECTIVES This study was designed to review the incidence of arthroscopically detected intra-articular loose bodies found in patients after traumatic hip dislocation or small acetabular wall fracture which would not otherwise be treated without surgery. DESIGN Retrospective review. SETTING Level 1 academic trauma center. PATIENTS Thirty-six patients(More)