Laurence A. Giroldi

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Sir, We read with great interest the paper by Bao et al (2014) entitled 'COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1', showing upregulation of Snail and down-regulation of E-cadherin in the human epithelial intestinal cell line HIEC overexpressing COUP-TFII upon transfection (Bao et al, 2014; Figure 5) and converse(More)
Changes in cadherin expression are instrumental both in embryonic development and disease, underlining the importance of understanding how cadherin expression is controlled. Kidney development is characterized by a mesenchymal-epithelial transition underlain by a cadherin-11 to cadherin-6 switch, the regulation mechanisms of which are presently unexplained.(More)
Please be advised that this information was generated on 2017-04-19 and may be subject to change. ABSTRACT Loss of E-cadherin-mediated adhesion is an important step in the progression of many carcinomas. In model systems, it has been shown that cadherin function requires not only proper E-cadherin expression but also its linkage to the cytoskeleton through(More)
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