Lauren Tyrell

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PURPOSE B-cell receptor signaling plays an important role in the pathogenesis of chronic lymphocytic leukemia (CLL). However, blocking B-cell receptor signaling with dasatinib, an inhibitor of SRC kinase, produced variable results in preclinical and clinical studies. We aim to define the molecular mechanisms underlying the differential dasatinib sensitivity(More)
Prostate cancer (PC) is the most common noncutaneous malignancy affecting men in the US, leading to significant morbidity and mortality. While significant therapeutic advances have been made, available systemic therapeutic options are lacking. Prostate-specific membrane antigen (PSMA) is a highly-restricted prostate cell-surface antigen that may be(More)
136 Background: J591 is a monoclonal antibody which selectively binds the external domain of PSMA with high affinity. Two phase I trials of radiolabeled-J591 have been published; two additional studies have been completed. 90Y is a beta-emitting particle optimal for tumor lesions 28-42 mm in size; 177Lu is best suited for lesions 1-3 mm in diameter(More)
TPS193 Background: Biochemical recurrence without evidence of PC on standard CT/MRI and bone scans after local therapy is common. Salvage radiotherapy affords a cure to select patients (pts) with PSA relapse, but most progress because of micrometastatic PC outside of the radiation field. J591 is a monoclonal antibody that targets the extracellular domain of(More)
e15186 Background: J591 is a monoclonal antibody which selectively binds the external domain of PSMA with no direct effect on PSA expression or secretion. Two phase I trials of radiolabeled (RL)-J591 are published; 2 additional studies have been presented. 90Y is a beta-emitter optimal for tumor lesions 28-42 mm; 177Lu is best suited for 1-3 mm lesions. (More)
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