Lauren Rhea Mitchell

Learn More
Signal processing for magnetic resonance force microscopy by<lb>Michael Y. J. Ting Chair: Alfred O. Hero III Magnetic resonance force microscopy (MRFM) is an emergent technology that has<lb>the potential for three-dimensional, non-destructive, and in-situ imaging of biological<lb>molecules with atomic resolution. Experiments at IBM have shown that MRFM(More)
PURPOSE Radiotherapy has a central role in the treatment of non-small cell lung cancer. Effectiveness of this modality, however, is often limited as resistance results from defects in cell death. EXPERIMENTAL DESIGN We investigated whether simultaneous up-regulation of apoptosis, via Bcl-2 inhibitor ABT-737, and autophagy, via mammalian target of(More)
Aurora kinase B (AURKB) is critical to the process of mitosis, aiding in chromosome condensation by phosphorylating histone H3. We investigated the effects of AZD1152, an AURKB inhibitor, on radiosensitivity of androgen-insensitive prostate cancer cells. The goal of this study was to test whether AZD1152 increases the susceptibility of hormone-refractory(More)
Since apoptosis defects limit efficacy of anti-cancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiation triggers autophagy in(More)
BACKGROUND Achieving therapeutic levels of cyclosporine (CSA) or Tacrolimus (TAC) early post lung transplantation (LTx) is challenging. Gut dysmotility, renal dysfunction and seizure risk are variably present and problematic. This study reports a single center. MATERIAL AND METHODS All adult LTx recipients from Aug 06-Aug 11 were divided into 4 cohorts:(More)
As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiation triggers autophagy in(More)
In vertebrate embryos, the dorsal aorta and the posterior cardinal vein form in the trunk to comprise the original circulatory loop. Previous studies implicate Hedgehog (Hh) signaling in the development of the dorsal aorta. However, the mechanism controlling specification of artery versus vein remains unclear. Here, we investigated the cell-autonomous(More)
Southern flying squirrels (Glaucomys volans) from southeastern Georgia were examined for ectoparasites and gastrointestinal helminths. Ten species of ectoparasites were recovered, including 3 species of sucking lice (Hoplopleura trispinosa, Microphthirus uncinatus, and Neohaematopinus sciuropteri), 1 species of flea (Orchopeas howardi), 2 species of ticks(More)
In recent years, the discovery of antibodies to specific neuronal antigens that then go on to cause encephalitis has gone a long way to change the investigation and management of a potential encephalitic process. These have now become known under the umbrella term of the ‘autoimmune encephalitides’. In this article we look at antiN-methyl-D-aspartate(More)