Lauren Morgan

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The E4 allele of the apolipoprotein E gene (APOE) is a major risk factor for late-onset Alzheimer's disease (LOAD) but is neither necessary nor sufficient to cause the disease. In this study, we investigated polymorphisms in the presenilin-1 (PS-1), and butyrylcholinesterase (BChE) genes, which have been implicated as risk factors for LOAD. Our data-set(More)
Angiotensinogen is the only known substrate for the enzyme renin. Angiotensin II, the end product of the reaction, is an extremely potent vasoconstrictor and a major determinant of salt and water homeostasis. It is also a growth factor. Angiotensinogen has been identified as a non-inhibitory member of the serine proteinase inhibitor family. Although the(More)
There is biochemical and animal model evidence supporting a pathological role of the ACT gene in AD. However, direct genetic evidence remains controversial and has been mostly limited to individual single nucleotide polymorphism (SNP) analysis. To resolve this apparent conflict we have used a high-density ACT SNP map, constructed haplotypes and explored(More)
BACKGROUND We previously developed and validated the Oxford NOTECHS rating system for evaluating the non-technical skills of an entire operating theatre team. Experience with the scale identified the need for greater discrimination between levels of performance within the normal range. We report here the development of a modified scale (Oxford NOTECHS II)(More)
OBJECTIVE To compare the angiotensinogen genotypes in normotensive and pre-eclamptic pregnancies in maternal and fetal samples. DESIGN Prospective observational study. SETTING University Hospital, Queen's Medical Centre, Nottingham. POPULATION Forty-three women with pre-eclampsia and 84 normotensive pregnant women. Fetal samples were available for(More)
OBJECTIVES To evaluate the effectiveness of aviation-style teamwork training in improving operating theatre team performance and clinical outcomes. SETTING 3 operating theatres in a UK district general hospital, 1 acting as a control group and the other 2 as the intervention group. PARTICIPANTS 72 operations (37 intervention, 35 control) were observed(More)
OBJECTIVE To investigate the fetal angiotensin II type 1 receptor genotype in pre-eclampsia. DESIGN Case-control study. POPULATION Forty-one maternal-fetal pairs from pre-eclamptic pregnancies and 80 maternal-fetal pairs from normotensive pregnancies. METHODS Maternal and fetal DNA was genotyped at three diallelic polymorphisms, at nucleotides 573,(More)
OBJECTIVE To investigate the hypothesis that pre-eclampsia is associated with a common insertion-deletion polymorphism in the angiotensin-converting enzyme gene. DESIGN Seventy-two women with pre-eclampsia and 83 normotensive pregnant women participated in the study. Pre-eclampsia was defined as a blood pressure exceeding 140/90 mm Hg in a previously(More)
BACKGROUND Modern medical care requires numerous patient handovers/handoffs. Handover error is recognised as a potential hazard in patient care, and the information error rate has been estimated at 13%. While accurate, reliable handover is essential to high quality care, uncertainty exists as to how intrahospital handover can be improved. This systematic(More)