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The E4 allele of the apolipoprotein E gene (APOE) is a major risk factor for late-onset Alzheimer's disease (LOAD) but is neither necessary nor sufficient to cause the disease. In this study, we investigated polymorphisms in the presenilin-1 (PS-1), and butyrylcholinesterase (BChE) genes, which have been implicated as risk factors for LOAD. Our data-set(More)
Angiotensinogen is the only known substrate for the enzyme renin. Angiotensin II, the end product of the reaction, is an extremely potent vasoconstrictor and a major determinant of salt and water homeostasis. It is also a growth factor. Angiotensinogen has been identified as a non-inhibitory member of the serine proteinase inhibitor family. Although the(More)
OBJECTIVES To evaluate the effectiveness of aviation-style teamwork training in improving operating theatre team performance and clinical outcomes. SETTING 3 operating theatres in a UK district general hospital, 1 acting as a control group and the other 2 as the intervention group. PARTICIPANTS 72 operations (37 intervention, 35 control) were observed(More)
BACKGROUND Teamwork training and system standardisation have both been proposed to reduce error and harm in surgery. Since the approaches differ markedly, there is potential for synergy between them. METHODS DESIGN Controlled interrupted time series with a 3 month intervention and observation phases before and after. SETTING Operating theatres(More)
OBJECTIVES To develop a sensitive, reliable tool for enumerating and evaluating technical process imperfections during surgical operations. DESIGN Prospective cohort study with direct observation. SETTING Operating theatres on five sites in three National Health Service Trusts. PARTICIPANTS Staff taking part in elective and emergency surgical(More)
OBJECTIVE To investigate the hypothesis that the genotype at nucleotide A(-20)C in the 5' flanking region of the angiotensinogen gene, which lies within a sequence with high homology to an oestrogen response element, affects plasma angiotensinogen levels in pregnancy. DESIGN Prospective observational study METHODS Seventy-two healthy pregnant women were(More)
BACKGROUND We previously developed and validated the Oxford NOTECHS rating system for evaluating the non-technical skills of an entire operating theatre team. Experience with the scale identified the need for greater discrimination between levels of performance within the normal range. We report here the development of a modified scale (Oxford NOTECHS II)(More)
This study investigates the reliability of glycated haemoglobin, measured by electroendosmosis or by affinity chromatography, fructosamine, and albumin adjusted fructosamine, as indices of glycaemic control in Type 1 diabetes complicated by chronic renal failure. Twenty uraemic diabetic patients took part in the study, including 5 patients managed(More)
OBJECTIVE To investigate the hypothesis that pre-eclampsia is associated with a common insertion-deletion polymorphism in the angiotensin-converting enzyme gene. DESIGN Seventy-two women with pre-eclampsia and 83 normotensive pregnant women participated in the study. Pre-eclampsia was defined as a blood pressure exceeding 140/90 mm Hg in a previously(More)