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We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1.6-2.0 x LD50 soman exposure, to analyse the molecular mechanism of neuronal damage and to screen effective neuroprotectants against cholinergic agonist and chemical warfare nerve agent (CWNA) exposure. Rats implanted with radiotelemetry probes capable of(More)
BACKGROUND Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in polyvinyl chloride products. DEHP exposure, which is widespread in the US, increases preterm birth risk; however, the mechanisms driving this relationship are unclear. Because cyclooxygenase-2 (COX-2) dependent prostaglandin synthesis is implicated in preterm birth, we evaluated(More)
ii DEDICATION To my family and friends, iii ACKNOWLEDGEMENTS First and foremost, I would like to thank all members of my committee. I thank my mentor, Dr. Martin Philbert, for all of his support and guidance. I appreciate the opportunity to work under his mentorship and all his efforts to develop me as an independent research. I also thank Dr. Altschuler(More)
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