Lauren M Oldfield

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Recent scientific advances have significantly contributed to our understanding of the complex connection between the microbiome and cancer. Our bodies are continuously exposed to microbial cells, both resident and transient, as well as their byproducts, including toxic metabolites. Circulation of toxic metabolites may contribute to cancer onset or(More)
Here, we present a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools. We believe this method will enable more rapid and complex modifications of HSV-1 and other large DNA viruses than previous technologies, facilitating many useful applications. Yeast(More)
Methods of data collection for the 2nd Small Cell Lung Cancer Workshop are described, and data reliability is reviewed. The method of cluster analysis of the workshop antibodies is described and discussed. Of the 27,111 results submitted 20,705 were judged to be reliable for analysis and 13,802 of these came from immunohistology experiments. Data derived(More)
The delivery of large DNA vectors (>100 000 bp) remains a limiting step in the engineering of mammalian cells and the development of human artificial chromosomes (HACs). Yeast is commonly used to assemble genetic constructs in the megabase size range, and has previously been used to transfer constructs directly into cultured cells. We improved this method(More)
INTRODUCTION Aging increases the risk of both erectile dysfunction (ED) and cardiovascular disease. These conditions have similar etiologies and commonly coexist. One unifying concept is the role of arterial insufficiency which is a primary factor in the onset of age-related ED. AIM Based on the novel finding that the pudendal arteries contribute 70% of(More)
...........................................................................................................................................ii Co-Authorship ................................................................................................................................ iv(More)
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