Lauren M. Burcaw

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Interpreting brain diffusion MRI measurements in terms of neuronal structure at a micrometer level is an exciting unresolved problem. Here we consider diffusion transverse to a bundle of fibers, and show theoretically, as well as using Monte Carlo simulations and measurements in a phantom made of parallel fibers mimicking axons, that the time dependent(More)
The presence of micrometer-level restrictions leads to a decrease of diffusion coefficient with diffusion time. Here we investigate this effect in human white matter in vivo. We focus on a broad range of diffusion times, up to 600 ms, covering diffusion length scales up to about 30 μm. We perform stimulated echo diffusion tensor imaging on 5 healthy(More)
We present new NMR techniques to characterize food products that are based on the measurement of two-dimensional diffusion-T2 relaxation and T1-T2 relaxation distribution functions. These measurements can be performed in magnets of modest strength and low homogeneity and do not require pulsed gradients. As an illustration, we present measurements on a range(More)
In this paper we present a method to determine the pore and grain size heterogeneity using a correlation between the transverse relaxation time and the susceptibility induced inhomogeneous magnetic field. By using a CPMG echo train, we are able to correlate T(2) with the inhomogeneous internal magnetic field, B(z)(i). We first introduce a simple simulation(More)
Natural fluids, such as crude oils, are often mixtures of a broad range of different molecules, and in situ measurement of their composition is highly desirable. Furthermore, the relationship between their composition and their physical properties has always been a challenge for such mixtures. We have analyzed diffusion in alkane mixtures to find a power(More)
In experiments involving decaying signals, it is often desirable to analyze the data as a sum of exponential decays using the Laplace inversion method. However, Laplace inversion is an ill-conditioned problem, and it is difficult to ascertain the stability of the reconstruction method and resolution of the resulting spectrum. This paper provides an easily(More)
O1 Propagator-Resolved 2D Exchange in Porous Media in the Inhomogeneous Magnetic Field Lauren Burcaw 1, Mark Hunter 2, Paul Callaghan 2 1 Victoria University of Wellington, 2 SCPS, Victoria University of Wellington We present a propagator-resolved 2D exchange spectroscopy technique for observing fluid motion in a porous medium. The susceptibility difference(More)
We present a propagator-resolved 2D exchange spectroscopy technique for observing fluid motion in a porous medium. The susceptibility difference between the matrix and the fluid is exploited to produce an inhomogeneous internal magnetic field, causing the Larmor frequency to change as molecules migrate. We test our method using a randomly packed(More)
We present a new method for observing fluid diffusion in a porous medium. The method employs 2D exchange spectroscopy for molecules diffusing in the presence of local magnetic field inhomogeneities, in our case distilled water in various sized glass bead packs. Our experiment involves an acquisition and evolution time domain with the two Fourier domains(More)
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