Lauren K . Tyra

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How cellular stresses up-regulate autophagy is not fully understood. One potential regulator is the Drosophila melanogaster protein Acinus (Acn), which is necessary for autophagy induction and triggers excess autophagy when overexpressed. We show that cell type-specific regulation of Acn depends on proteolysis by the caspase Dcp-1. Basal Dcp-1 activity in(More)
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 2 253–268 JCB 253 Correspondence to Helmut Krämer: Abbreviations used in this paper: Acn, Acinus; ASAP, apoptosisand splicingassociated protein; Da, Daughterless; ERG, electroretinogram; GMR, glass multimer reporter;(More)
Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn(More)
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