Lauren J. Sweeney

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In 39 out of 95 normal specimens, there was either no commissure between the anterior and medial leaflets of the tricuspid valve, which resulted in an interrupted valve margin at the center of the membranous ventricular septum, or an incompletely formed commissure. It is suggested that one end of this spectrum of normal anatomic variations could have a(More)
This anatomic study suggests that an understanding of the thickness of the atrial septum should allow better visualization of most portions of the blade-shaped atrial septum during cross-sectional echocardiography, both in normal subjects and in patients with ostium secundum atrial septal defects. The thickness measurements also demonstrate that(More)
The atrial septum is a blade-shaped structure with a concave anterior margin that reflects the curve of the ascending aorta, a convex posterior margin, and an inferior margin along the mitral annulus. The fossa ovalis comprises an average of 28 per cent of the total septal area, or 43 mm.2 in infants and 240 mm.2 in adults. The channel that persists between(More)
The relationship of the base of the left and noncoronary sinuses of the aortic valve and the adjacent aortic leaflet of the mitral valve was studied in 106 normal heart specimens and 184 specimens with isolated VSD. The results show a spectrum of persistence of the tissue along the inner curvature of the heart. This may help settle the recent controversy in(More)
The commissure between the anterior and medial leaflets of the tricuspid valve is commonly absent in Down's syndrome without endocardial cushion defect (19 of 28 specimens). As a result, aneurysm of the membranous ventricular septum may develop (eight of 14 specimens with ventricular septal defect limited to the membranous ventricular septum) and the(More)
We compared semilunar valve relationships of 26 normal hearts with 66 specimens with transposition of the great arteries (TGA). The TGA hearts exhibited a spectrum of dextroposition of the aorta, which brought the point of fibrous continuity between aortic and pulmonary valves 15 to 120° closer to the tricuspid annulus than in the normal specimen. Aortic(More)
A study of heart specimens without ventricular septal defect from patients with down's syndrome showed a significant enlargement of the membranous ventricular septum as compared to the normal heart. This increase in area of the ventricular septum occupied by membranous tissue from 2 to 9% may not only predispose patients with Down's syndrome to congenital(More)