Lauren B. Kaufman

Learn More
The signal-to-noise ratio (S/N) in magnetic resonance imagining is one of the variables that must be measured when comparing the relative performance of different techniques. Although various investigators and official groups have proposed different methods for measuring S/N, these are generally not practical for use by a physician working in a clinical(More)
In investigating six cases of blastomycosis in two school groups that had separately visited an environmental camp in northern Wisconsin in June 1984, we identified a large outbreak of the disease and isolated Blastomyces dermatitidis from soil at a beaver pond near the camp. Of 89 elementary-school children and 10 adults from the two groups, 48 (51(More)
Conjugation can be used to synthesize half of the data acquired during a conventional two-dimensional Fourier transform imaging procedure, thus reducing imaging time by nearly half. The images acquired by this process have the same object contrast and spatial resolution as conventional images do, but with a 40% reduction in the signal-to-noise ratio (S/N).(More)
One hundred ninety-four patients with cryptococcal meningitis were enrolled in a multicenter, prospective, randomized clinical trial to compare the efficacy and toxicity of four as compared with six weeks of combination amphotericin B and flucytosine therapy. Among 91 patients who met preestablished criteria for randomization, cure or improvement was noted(More)
Blastomycosis cannot yet be prevented or controlled, in part because the natural habitat of the causative fungus, Blastomyces dermatitidis, remains ill defined. In investigating 2 outbreaks of blastomycosis that occurred in the summer of 1985 among persons engaged in activities along rivers in contiguous central Wisconsin counties, we isolated B.(More)
Sixty-eight patients with a wide spectrum of brain pathology were imaged with both computed tomography (CT) using a G.E. 8800 scanner and nuclear magnetic resonance (NMR) imaging with a 3.5 kG prototype device. NMR was more advantageous in the detection and/or characterization of pathology in 20 of the 68 patients, especially when demyelination was part of(More)
The potential clinical importance of T1 and T2 relaxation times in distinguishing normal and pathologic tissue with magnetic resonance (MR) is discussed and clinical examples of cerebral abnormalities are given. T1 and T2 values may be used in three ways: (a) Relative values, obtained by an analysis of intensity images with varying dependence on T1 and T2,(More)
Nuclear magnetic resonance (NMR) imaging with spin-echo techniques defines vascular structures with superb anatomic detail. Contrast agents are not necessary as there is intrinsic contrast between flowing blood and the vascular wall. The signal intensity from blood within the vessel lumen varies with the sequence of gradient and radiofrequency pulses used(More)