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OBJECTIVES Placental antibody transfer is impaired in the context of HIV infection, which may render HIV-exposed, uninfected infants vulnerable to group B Streptococcus (GBS) disease. The GBS antibody response predominately consists of immunoglobulin G2 (IgG2) antibody. Thus we determined whether concentration and placental transfer of anti-GBS antibody(More)
BACKGROUND HIV-exposed uninfected infants have increased infection risk and mortality compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of invasive GBS disease due to reduced maternal antibody against GBS. METHODS We quantified antibodies that bind to the surface of whole Group B Streptococcus (GBS) of serotypes Ia, Ib, II,(More)
Acknowledgements There are many people who have helped me complete this study that I want to thank. First, thank you to my thesis reader, Professor Magilke, who has provided me with much guidance and advice during the entire process of writing my thesis. He has met with me numerous times during this semester, and I cannot thank him enough for all of his(More)
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