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Atrial natriuretic peptide is negatively regulated by microRNA-425.

• Pankaj Kumar Arora, Connie K. Wu, +23 authors Thomas J. Wang
• The Journal of clinical investigation
• 2013

Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3'… (More)

Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice.

• Emmanuel S Buys, Michael J. Raher, +18 authors Kenneth D. Bloch
• The Journal of clinical investigation
• 2012

Nitric oxide (NO) plays an essential role in regulating hypertension and blood flow by inducing relaxation of vascular smooth muscle. Male mice deficient in a NO receptor component, the α1 subunit of… (More)

Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma.

• Emmanuel S Buys, Yu-Chieh Ko, +27 authors Bruce R Ksander
• PloS one
• 2013

Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the α1… (More)

Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia

• Guo Ling Zhou, Arkadi Beloiartsev, +8 authors Kenneth D. Bloch
• PLoS genetics
• 2013

Epoxyeicosatrienoic acids (EETs) confer vasoactive and cardioprotective functions. Genetic analysis of the contributions of these short-lived mediators to pathophysiology has been confounded to date… (More)

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.

• Ana C. Dordea, Sara Vandenwijngaert, +21 authors Emmanuel S Buys
• American journal of physiology. Heart and…
• 2016

Dysregulated nitric oxide (NO) signaling contributes to the pathogenesis of hypertension, a prevalent and often sex-specific risk factor for cardiovascular disease. We previously reported that mice… (More)

sGCα1-deficient mice: a novel murine model of spontaneous primary open angle glaucoma

• Emmanuel S Buys, Yu-Chieh Ko, +12 authors Bruce R Ksander
• 2011

Background Primary open angle glaucoma (POAG) is a progressive eye disease that leads to blindness due to the irreversible loss of retinal ganglion cells and degeneration of the optic nerve (ON). As… (More)

Weight Loss, Saline Loading, and the Natriuretic Peptide System

• Pankaj Kumar Arora, Jason Reingold, +17 authors Thomas J. Wang
• Journal of the American Heart Association
• 2015

BACKGROUND In epidemiologic studies, obesity has been associated with reduced natriuretic peptide (NP) concentrations. Reduced NP production could impair the ability of obese individuals to respond… (More)

Genetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase α1 deficient mice

• Emmanuel S Buys, Michael J. Raher, +6 authors Kenneth D. Bloch
• 2011

Background We previously reported that male mice deficient in the a1 subunit of the NO receptor soluble guanylate cyclase (sGCa1 -/mice), an important nitric oxide (NO) receptor, are hypertensive… (More)

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