Learn More
Myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events. In this study we investigated the role of acto-myosin contractility, and its main regulators, i.e. myosin light chain kinase (MLCK) and Rho-kinase (ROCK) in cell survival in normal and Ras-transformed MCF-10A epithelial(More)
BACKGROUND Recurrent 15q13.3 microdeletions were recently identified with identical proximal (BP4) and distal (BP5) breakpoints and associated with mild to moderate mental retardation and epilepsy. METHODS To assess further the clinical implications of this novel 15q13.3 microdeletion syndrome, 18 new probands with a deletion were molecularly and(More)
The pharmaceutical industry is at a critical point in its relationship to society. Much of the early promise of the pharmaceutical industry in revolutionizing health care has not continued, with pipelines for innovative drugs drying up (including in critical areas such as neglected diseases [1]), an increasing number of me-too drugs flooding the market, and(More)
The use of mobile electronic devices to support medical or public health practice, or m-health, is currently a hot topic. It has been predicted that by 2017 there will be ''more mobile phones than people'' on the planet [1], and currently three-quarters of the world's population have access to a mobile phone [2]. The World Health Organization (WHO) has(More)
Noncommunicable diseases (NCDs), most often defined as chronic medical diseases including cardiovascular diseases (heart disease and stroke), cancer, chronic respiratory diseases (chronic obstructive pulmonary disease and asthma), and diabetes [1], are responsible for two-thirds of the world's deaths, one-fourth of which occur before the age of 60 years(More)
Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.human-phenotype-ontology.org) project are the phenotype vocabulary, disease-phenotype annotations and the(More)
A year and a half ago, PLOS Medicine announced a collaboration with the World Health Organization (WHO), inviting submission of articles to PLOS Medicine on the theme of ''no health without research'' [1]. That call for papers was intended to culminate in an open-access collection of original research and commentary articles to coincide with the launch in(More)
[1], PLOS Medicine is launching a new Reporting Guidelines Collection [2], an open access collection of reporting guidelines , commentary, and related research on guidelines from across PLOS journals. This collection is consistent with the goals of the Peer Review Congress: ''to improve the quality and credibility of scientific peer review and publication(More)
Last month, the United States Supreme Court struck down a patent claim by Myriad Genetics on the BRCA1 and BRCA2 genes [1]. The case, Association for Molecular Pathology v. Myriad Genetics , considered whether genes isolated in the lab are ''products of nature'' that may not be patented or are ''human-made inventions'' that would be eligible for patent(More)
In the October editorial, the PLOS Medicine Editors argue that the health of poor people in rich countries is of global significance and discuss why Open Access journals are particularly well suited to facilitate research and commentary on this topic. Please see later in the article for the Editors' Summary.