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Global regulation of heterochromatin spreading by Leo1
Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanismsExpand
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A New Isoform of the Histone Demethylase JMJD2A/KDM4A Is Required for Skeletal Muscle Differentiation
In proliferating myoblasts, muscle specific genes are silenced by epigenetic modifications at their promoters, including histone H3K9 methylation. Derepression of the promoter of the gene encodingExpand
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Rôle de l'histone déméthylase JMJD2A dans la régulation transcriptionnelle au cours de la différentiation musculaire
La chromatine est une structure dynamique, qui peut etre modulee par divers mecanismes, dont la methylation des histones. L'etat plus ou moins compacte de la chromatine est une composante importanteExpand