Laura Williams

Learn More
We assessed the test characteristics of 2 influenza antigen tests, a rapid immunoassay and a direct fluorescence antibody (DFA) assay, in detecting pandemic influenza A (H1N1) in children up to 18 years of age, using polymerase chain reaction as the standard. The sensitivities of BinaxNOW (59.6%) and direct fluorescence antibody (57.3%) were similar. The(More)
BACKGROUND Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. AIM To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. (More)
OBJECTIVE The purpose of this study was to determine whether the candidate genes previously studied in subjects with cleft lip, cleft palate, or both are associated with hypodontia outside the region of the cleft. SUBJECTS One hundred twenty subjects from the Iowa Craniofacial Anomalies Research Center were selected based on the availability of both(More)
A series of paclitaxel prodrugs designed for formulation in lipophilic nanoparticles are described. The hydrophobicity of paclitaxel was increased by conjugating a succession of increasingly hydrophobic lipid anchors to the drug using succinate or diglycolate cross-linkers. The prodrugs were formulated in well defined block copolymer-stabilized(More)
A high-throughput RapidFire mass spectrometry assay is described for the JMJD2 family of Fe(2+), O(2), and α-ketoglutarate-dependent histone lysine demethylases. The assay employs a short amino acid peptide substrate, corresponding to the first 15 amino acid residues of histone H3, but mutated at two positions to increase assay sensitivity. The assay(More)
Two of the most popular forms of protein on the market are whey and casein. Both proteins are derived from milk but each protein differs in absorption rate and bioavailability, thus it is possible that each type of protein may contribute differently to the adaptations elicited through resistance training. Therefore, the purpose of this study was to(More)
The purpose of this study was to examine the effects of a commercially available thermogenic product (TP) on resting energy expenditure (REE) and hemodynamic variables in a randomized, double-blind, placebo (PL)-controlled study. Eight male (age: 23.0 +/- 3.70 years, weight: 95.77 +/- 16.44 kg, height: 182.4 +/- 7.87 cm) and 10 female (age: 23.6 +/- 4.81(More)
The ingress of particulate material into freshwater spawning substrates is thought to be contributing to the declining success of salmonids reported over recent years for many rivers. Accordingly, the need for reliable information on the key sources of the sediment problem has progressed up the management agenda. Whilst previous work has focussed on(More)
The pathogenesis of adult-onset primary dystonia remains poorly understood. There is variable age-related and gender-related expression of the phenotype, the commonest of which is cervical dystonia. Endophenotypes may provide insight into underlying genetic and pathophysiological mechanisms of dystonia. The temporal discrimination threshold (TDT)-the(More)
PURPOSE The purpose of this study was to investigate the effect of experimental control mechanisms, simulated active (tendon-driven) and passive (externally assisted), on carpal motion. METHODS Kinematics of the carpal bones in five fresh-frozen cadaver upper extremities were studied using an optical motion analysis system. The wrist extensors and flexors(More)