Laura Wexler

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Philip Greenland, MD, Chair; Jonathan Abrams, MD; Gerard P. Aurigemma, MD; M. Gene Bond, PhD; Luther T. Clark, MD; Michael H. Criqui, MD; John R. Crouse III, MD; Lawrence Friedman, MD; Valentin Fuster, MD, PhD; David M. Herrington, MD, MHS; Lewis H. Kuller, MD, DrPH; Paul M. Ridker, MD, MPH; William C. Roberts, MD; William Stanford, MD; Neil Stone, MD; H.(More)
Isolated single coronary artery is a rare congenital anomaly occuring in approximately 0.024% of the population. This entity can be diagnosed during life only by coronary angiography. Ten patients with isolated single coronary artery are reported. Based on angiographic analysis, a new classification is proposed, according to the site of origin and(More)
CONTEXT A low plasma level of high-density lipoprotein cholesterol (HDL-C) is a major risk factor for coronary heart disease (CHD). A secondary prevention study, the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT), demonstrated that CHD events were significantly reduced during a median follow-up of 5.1 years by treating patients with(More)
BACKGROUND Heart failure is a highly prevalent disorder that continues to be associated with repeated hospitalizations, high morbidity, and high mortality. Sleep-related breathing disorders with repetitive episodes of asphyxia may adversely affect heart function. The main aims of this study were to determine the prevalence, consequences, and differences in(More)
PURPOSE To evaluate the accuracy of computed tomographic (CT) angiography in the detection of renal artery stenosis (RAS). MATERIALS AND METHODS CT angiography was performed in 31 patients undergoing conventional renal arteriography. CT angiographic data were reconstructed with shaded surface display (SSD) and maximum-intensity projection (MIP). Stenosis(More)
BACKGROUND Non-Q-wave myocardial infarction is usually managed according to an "invasive" strategy (i.e., one of routine coronary angiography followed by myocardial revascularization). METHODS We randomly assigned 920 patients to either "invasive" management (462 patients) or "conservative" management, defined as medical therapy and noninvasive testing,(More)
OBJECTIVES The purpose of this study was to determine whether central sleep apnea (CSA) contributes to mortality in patients with heart failure (HF). BACKGROUND Cheyne-Stokes breathing with CSA commonly occurs in patients with systolic HF. Consequences of CSA, including altered blood gases and neurohormonal activation, could result in further left(More)
BACKGROUND Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS Using the Get With the Guidelines-Coronary Artery Disease database, we examined(More)
OBJECTIVE To determine the prevalence and effect of sleep-disordered breathing in ambulatory patients with stable, optimally treated congestive heart failure. DESIGN A prospective, longitudinal study. SETTING Referral sleep laboratory of a Department of Veterans Affairs medical center. PATIENTS 42 of the 48 eligible patients with stable congestive(More)