Laura Walter Perna

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OBJECTIVE To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences. DESIGN Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US. (More)
The epigenetic clock, in particular epigenetic pre-aging quantified by the so-called DNA methylation age acceleration, has recently been suggested to closely correlate with a variety of disease phenotypes. There remains a dearth of data, however, on its association with telomere length and frailty, which can be considered major correlates of age on the(More)
This paper reports preliminary evidence suggesting that measurements of free light-chain Ig (FLIg) in urine may represent quantitative markers ofin vivo polyclonal B-cell activation. Thus, longitudinal levels of urinary FLIg in patients with systemic lupus erythematosus (SLE) may be used to track or monitor thein vivo immunopathologic B-cell activity of SLE(More)
OBJECTIVES To examine the relationship of serum 25-hydroxy vitamin D3 with cognitive functioning in higher age, using an instrument covering multiple cognitive domains in a population-based study. DESIGN Follow-up study with measurement of vitamin D levels at baseline and assessment of cognitive functioning at year 5 follow-up. SETTING AND PARTICIPANTS(More)
Policymakers, practitioners, and scholars have directed tremendous attention to the goal of improving “student success.” Based on a review of largely discrete existing bodies of literature, this report proposes an overarching framework that policymakers, practitioners, and researchers can use to develop, implement, and evaluate policies and practices for(More)
BACKGROUND Serum 25-hydroxyvitamin D [25(OH)D] concentration has been linked to mortality in several studies, but appropriate cutoffs to define risk categories are under debate. OBJECTIVE We aimed to conduct a repeated-measurements analysis on the association of serum 25(OH)D concentrations with all-cause and cause-specific mortality, with particular(More)
Plausible mechanisms of how vitamin D deficiency may contribute to the development of diabetes mellitus have been proposed but longitudinal cohort studies have yielded heterogeneous results. In 7,791 initially diabetes-free participants of a German population-based cohort, aged 50–74 years, adjusted Cox regression models were employed to estimate hazard(More)
BACKGROUND Differences in life expectancy (LE) between social groups in a specific country are a fundamental measure of health inequalities within that country. Constant monitoring of these differences provides important information on the population's general health. The purpose of the present study is to explore and quantify the socio-economic differences(More)
The associations of circulating 25-hydroxyvitamin D [25(OH)D] concentrations with total and site-specific cancer incidence have been examined in several epidemiological studies with overall inconclusive findings. Very little is known about the association of vitamin D with cancer incidence in older populations. We assessed the association of pre-diagnostic(More)