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Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression
Postoperative cognitive dysfunction (POCD) is a decline in cognitive performance after a surgery performed under anaesthesia. The exact roles of surgery and/or anaesthesia for facilitating POCD areExpand
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Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum
Background Whether the occurrence of postoperative cognitive dysfunction is a result of the effects of surgery or anesthesia is under debate. In this study, we investigated the impact of sevofluraneExpand
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Transgenic Alzheimer Mice Have a Larger Minimum Alveolar Anesthetic Concentration of Isoflurane than Their Nontransgenic Littermates
BACKGROUND: More than 12% of all people older than 65 yr have Alzheimer's disease. Because nothing is known about changes in demand of volatile anesthetics in this disease, we determined minimumExpand
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Effects of isoflurane-induced anaesthesia on cognitive performance in a mouse model of Alzheimer's disease: A randomised trial in transgenic APP23 mice
BACKGROUND Results from in-vitro experiments suggest that inhalational anaesthetics may have a detrimental effect on the course and incidence of Alzheimer's disease. However, case–control studies inExpand
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Neurologische und kognitive Leistungsfähigkeit nach tief hypothermem Kreislaufstillstand bei der Ratte - Etablierung eines neuen Modells
Herzchirurgische Operationen bei Kindern und Erwachsenen, die einen tief hypothermen Kreislaufstillstand (DHCA) erfordern, konnen zu zentralnervosen Defiziten fuhren. Ziel der vorliegenden Studie istExpand