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  • Fan Wang, Wensi Song, Giovanna Brancati, Laura Segatori
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2011 (First Publication: 17 October 2011)
  • Background: Lysosomal storage disorders are caused by ER-associated degradation (ERAD) of mutated unstable lysosomal enzymes. Results: ERAD inhibition enhances folding and activity of unstableExpand
  • Wensi Song, Fan Wang, +4 authors Laura Segatori
  • Medicine, Biology
  • Human molecular genetics
  • 2013 (First Publication: 15 May 2013)
  • Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead toExpand
  • Wensi Song, Fan Wang, Parisa Lotfi, Marco Sardiello, Laura Segatori
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2014 (First Publication: 20 February 2014)
  • Background: The drug delivery vehicle 2-hydroxypropyl-β-cyclodextrin (HPβCD) prevents cholesterol storage. Results: HPβCD treatment induces TFEB mediated activation of autophagy and clearance of theExpand