Laura Sacolick

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A novel method for amplitude of radiofrequency field (B1+) mapping based on the Bloch-Siegert shift is presented. Unlike conventionally applied double-angle or other signal magnitude-based methods, it encodes the B(1) information into signal phase, resulting in important advantages in terms of acquisition speed, accuracy, and robustness. The Bloch-Siegert(More)
Time-dependent variations in the brain temperature (Tt) are likely to be caused by fluctuations of cerebral blood flow (CBF) and cerebral metabolic rate of oxidative consumption (CMRO2) both of which are seemingly coupled to alterations in neuronal activity. We combined magnetic resonance, optical imaging, temperature sensing, and electrophysiologic methods(More)
Current spokes pulse design methods can be grouped into methods based either on sparse approximation or on iterative local (gradient descent-based) optimization of the transverse-plane spatial frequency locations visited by the spokes. These two classes of methods have complementary strengths and weaknesses: sparse approximation-based methods perform an(More)
UNLABELLED MR-based attenuation correction is instrumental for integrated PET/MR imaging. It is generally achieved by segmenting MR images into a set of tissue classes with known attenuation properties (e.g., air, lung, bone, fat, soft tissue). Bone identification with MR imaging is, however, quite challenging, because of the low proton density and fast(More)
UNLABELLED Ultrashort-echo-time (UTE) sequences have been proposed in the past for MR-based attenuation correction of PET data, because of their ability to image cortical bone. In the present work we assessed the limitations of dual-echo UTE imaging for bone segmentation in head and neck imaging. Sequentially acquired MR and PET/CT clinical data were used(More)
In vivo multivoxel Magnetic Resonance Spectroscopy (MRS) and multislice Magnetic Resonance Spectroscopic Imaging (MRSI) are extremely susceptible to poor homogeneity of the static magnetic field. Existing room-temperature (RT) shim technology can adequately optimize the B(0) homogeneity of local volumes, such as single voxels. However, the widespread global(More)
The capability of magnetic resonance imaging (MRI) to produce spatially resolved estimation of tissue electrical properties (EPs) in vivo has been a subject of much recent interest. In this work we introduce a method to map tissue EPs from low-flip-angle, zero-echo-time (ZTE) imaging. It is based on a new theoretical formalism that allows calculation of EPs(More)
PURPOSE To develop a simple correction approach to mitigate shading in 3 Tesla (T) breast MRI. MATERIALS AND METHODS A slightly modified breast receive (Rx) array, which we termed field shaping array (FSA), was shown to mitigate breast shading at 3T. In this FSA, one Rx element was selectively unblocked and tuned off the Larmor frequency during the(More)
PURPOSE To investigate proton density (PD)-weighted zero TE (ZT) imaging for morphological depiction and segmentation of cranial bone structures. METHODS A rotating ultra-fast imaging sequence (RUFIS) type ZT pulse sequence was developed and optimized for 1) efficient capture of short T2 bone signals and 2) flat PD response for soft-tissues. An inverse(More)
Transmit gain (B 1+) calibration is necessary for the adjustment of radiofrequency (RF) power levels to the desired flip angles. In proton MRI, this is generally an automated process before the actual scan without any user interaction. For other nuclei, it is usually time consuming and difficult, especially in the case of hyperpolarised MR. In the current(More)