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The skin microbiome: Associations between altered microbial communities and disease
A single square centimetre of the human skin can contain up to one billion microorganisms. These diverse communities of bacteria, fungi, mites and viruses can provide protection against disease, butExpand
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From the field to the laboratory: Controlling DNA contamination in human ancient DNA research in the high-throughput sequencing era
Abstract High-Throughput DNA Sequencing (HTS) technologies have changed the way in which we detect and assess DNA contamination in ancient DNA studies. Researchers use computational methods to mineExpand
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Role of the Type III Secretion System in a Hypervirulent Lineage of Bordetella bronchiseptica
ABSTRACT Despite the fact that closely related bacteria can cause different levels of disease, the genetic changes that cause some isolates to be more pathogenic than others are generally not wellExpand
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Laboratory contamination over time during low‐biomass sample analysis
Bacteria are not only ubiquitous on earth but can also be incredibly diverse within clean laboratories and reagents. The presence of both living and dead bacteria in laboratory environments andExpand
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Resident microbiota affect Bordetella pertussis infectious dose and host specificity.
Before contacting host tissues, invading pathogens directly or indirectly interact with host microbiota, but the effects of such interactions on the initial stages of infection are poorly understood.Expand
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Lack of Cross-protection against Bordetella holmesii after Pertussis Vaccination
Vaccines for B. pertussis do not protect against circulating strains of a closely related respiratory pathogen.
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Type Six Secretion System of Bordetella bronchiseptica and Adaptive Immune Components Limit Intracellular Survival During Infection
The Type Six Secretion System (T6SS) is required for Bordetella bronchiseptica cytotoxicity, cytokine modulation, infection, and persistence. However, one-third of recently sequenced BordetellaExpand
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A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo
Type VI Secretion Systems (T6SSs) have been identified in numerous Gram-negative pathogens, but the lack of a natural host infection model has limited analysis of T6SS contributions to infection andExpand
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Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice.
Growing epidemiological evidence links natural green space exposure with a range of health benefits, including for mental health. Conversely, greater urbanisation associates with increased risk ofExpand
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Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice
Antibody‐mediated immunity is highly protective against disease. The majority of current vaccines confer protection through humoral immunity, but there is high variability in responsiveness acrossExpand
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