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INTRODUCTION Dual mobility cups are especially indicated in total hip replacement revision, the risk of recurrent instability being greater than in primary surgery. In revision, however, primary cup fixation is uncertain without routine anchoring screws. HYPOTHESIS The stability of dual mobility cups impacted without cement, supplementary screw(s) or(More)
The cellular prion protein was historically characterized owing to its misfolding in prion disease. Although its physiological role remains incompletely understood, PrP(C) has emerged as an evolutionary conserved, multifaceted protein involved in a wide-range of biological processes. PrP(C) is a GPI-anchored protein targeted to the plasma membrane, in raft(More)
BACKGROUND & AIMS Cell adhesion is one function regulated by cellular prion protein (PrP(c)), a ubiquitous, glycosylphosphatidylinositol-anchored glycoprotein. PrP(c) is located in cell-cell junctions and interacts with desmosome proteins in the intestinal epithelium. We investigated its role in intestinal barrier function. METHODS We analyzed(More)
We reported previously that the cellular prion protein (PrP(c)) is a component of desmosomes and contributes to the intestinal barrier function. We demonstrated also the presence of PrP(c) in the nucleus of proliferating intestinal epithelial cells. Here we sought to decipher the function of this nuclear pool. In human intestinal cancer cells Caco-2/TC7 and(More)
INTRODUCTION Metastatic malignant tumors of the hand are unusual. We describe a patient with gastric cancer. OBSERVATION A 64-year-old man in remission of a gastric adenocarcinoma treated surgically one year previously was admitted to hospital for a pain of the right hand associated with an edema. The radiography of the hand established an osteolysis of(More)
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