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The association between hyperinflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, nontranscriptional role of GPS2 as a guardian against hyperstimulation of the(More)
Cloud computing infrastructures support dynamical and flexible access to computational, network and storage resources. To date, several disjoint industrial and academic technologies provide infrastructure level access to Clouds. Especially for industrial platforms, the evolution of de-facto standards goes together with worries about user lock-in to a(More)
In this paper, we propose a new method, called Convergent Scheduling, for scheduling a continuous stream of batch jobs on the machines of large-scale computing farms. This method exploits a set of heuristics that guide the scheduler in making decisions. Each heuristics manages a specific problem constraint, and contributes to carry out a value that measures(More)
Massively Multiuser Virtual Environments (MMVEs) are attracting millions of players from all over the world. Currently used Client/Server infrastructures and technologies are reaching their limits of flexibility and scalability. We propose an approach that combines the technological advantages of two different paradigms, namely P2P networking and Cloud(More)
Estrogen receptor-α (ERα) has central role in hormone-dependent breast cancer and its ligand-induced functions have been extensively characterized. However, evidence exists that ERα has functions that are independent of ligands. In the present work, we investigated the binding of ERα to chromatin in the absence of ligands and its functions on gene(More)
Gossip-based Peer-to-Peer protocols proved to be very efficient for supporting dynamic and complex information exchange among distributed peers. They are useful for building and maintaining the network topology itself as well as to support a pervasive diffusion of the information injected into the network. This is very useful in a world where there is a(More)
Gossip-based Peer-to-Peer protocols proved to be very efficient for supporting dynamic and complex information exchange among distributed peers. They are useful for building and maintaining the network topology itself as well as to support a pervasive diffusion of the information injected into the network. This is very useful in a world where there is a(More)
We describe the main architecture and the design principles of the Service/Resource Discovery System (SRDS), a component of the XtreemOS Operating System. XtreemOS is a Linux extension that enables management and exploitation as single platform of computational resources provided by federated Virtual Organizations. The SRDS provides scalable and(More)
This paper presents a set of strategies for scheduling a stream of batch jobs on the machines of a heterogeneous computational farm. Our proposal is based on a flexible backfilling, which schedules jobs according to a priority assigned to each jobs submitted for the execution. Priority values are computed as a result of a set of heuristics whose main goal(More)