Laura Pla Beltran

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The correct functioning of critical infrastructures is crucial for modern society. These systems provide the backbone to our everyday lives and, therefore, securing and protecting them is a challenging yet vital issue. This project studies the vulnerabilities and protection challenges these systems present, and proposes a solution using a collaborative(More)
Lysosomal storage diseases (LSDs) are caused by accumulation of partially degraded substrates within the lysosome, as a result of a function loss of a lysosomal protein. Recombinant lysosomal proteins are usually produced in mammalian cells, based on their capacity to carry out post-translational modifications similar to those observed in human native(More)
Mucopolysaccharidosis IV A (MPS IV A, Morquio A disease) is a lysosomal storage disease (LSD) produced by mutations on N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Recently an enzyme replacement therapy (ERT) for this disease was approved using a recombinant enzyme produced in CHO cells. Previously, we reported the production of an active GALNS enzyme(More)
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