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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective degeneration of motor neurons, atrophy, and paralysis of skeletal muscle. Although a significant proportion of familial ALS results from a toxic gain of function associated with dominant SOD1 mutations, the etiology of the disease and its specific(More)
OBJECTIVES To study motor evoked potentials (MEPs) to multi-pulse transcranial electrical stimulation (MP-TES) during orthopaedic spinal surgery under different anaesthetic regimens. METHODS MEPs to MP-TES were recorded from tibialis anterior and abductor hallucis bilaterally in 50 operations. Anaesthesia was maintained with propofol and nitrous oxide in(More)
Event-related potentials (ERPs) were recorded to a digit-probe identification and matching task (modified 'Sternberg paradigm') in 29 patients with temporal lobe epilepsy (TLE) and 26 healthy subjects. Our main aim was to identify the neurophysiological correlates of abnormal short term memory function in patients with TLE. Neuropsychological tests allowed(More)
Auditory and visual event-related potentials were recorded during a short-term memory task in 24 patients who had recently presented with symptomatically and clinically isolated spinal cord syndromes suspected to be due to multiple sclerosis, and in 24 matched control subjects. Event-related potentials (ERPs) were recorded during two sequential components(More)
OBJECTIVES To study working memory function in untreated major depression using a digit probe identification and matching task. METHODS We compared behavioural performance and event-related potentials during processing of the Sternberg working memory task in 14 depressed patients and 14 healthy matched control subjects. RESULTS Patients made more(More)
This paper develops the hypothesis of different roles of the two hemispheres in imaginal processes. A test designated the "o'Clock Test" is proposed, which contains closely confrontable perceptual and imaginal tasks. It enables examination of the abilities both to generate mental images and to explore them in their right and left halves (R + L Condition).(More)
The time taken to scan short term memory for a target (probe) digit in the Sternberg paradigm is thought to be reflected in the latency of a major positive wave in the associated event-related potentials. In the present study we have recorded and analysed reaction time and event-related potentials to a digit probe identification task in 37 healthy subjects.(More)
A multimodal electrophysiological study, including median nerve somatosensory evoked potentials (SSEPs), motor cortical stimulation (CS) and brainstem evoked potentials (BAEPs), was performed on 34 patients with hereditary ataxias (HAs): 15 with Friedreich's disease (FD), 10 with early onset cerebellar ataxia (EOCA), and 9 with autosomal dominant cerebellar(More)
The effects of age on behavioural performance and event-related potentials recorded during a working memory task using digits presented either acoustically or visually, were studied in 37 healthy subjects with an age range from 19 to 71 years. With increasing age, psychological tests showed a progressive decline in visuo-spatial performance and both(More)
Any relationship between measures of cognitive function and brain electrical activity would be of considerable importance in the objective assessment of patients suspected of intellectual impairment. In healthy subjects, we have found a strong correlation between the event-related potentials evoked by a digit probe identification task and scores on(More)