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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
- Lauren L C Marotta, V. Almendro, +25 authors K. Polyak
- Biology, Medicine
- The Journal of clinical investigation
- 1 July 2011
Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in progression. We previously characterized… Expand
Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene
The karyotypic chaos exhibited by human epithelial cancers complicates efforts to identify mutations critical for malignant transformation. Here we integrate complementary genomic approaches to… Expand
Genome-wide functional synergy between amplified and mutated genes in human breast cancer.
A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical… Expand
CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer.
Genetically activated kinases have been attractive therapeutic targets in cancer due to the relative ease of developing tumor-specific treatment strategies for them. To discover novel putative… Expand
Interplay of Genes Regulated by Estrogen and Diindolylmethane in Breast Cancer Cell Lines
- Laura Mulvey, Alamelu Chandrasekaran, +4 authors L. Goodwin
- Chemistry, Medicine
- Molecular medicine
Diindolylmethane (DIM), a biologically active congener of indole-3-carbinol (I3C) derived from cruciferous vegetables, is a promising agent for the prevention of estrogen-sensitive cancers. Both DIM… Expand
You Are Where You Live: Using the size of conodont dental tools to shed light on environmental conditions and community complexity
One of the most versatile tools in a palaeontologists’ “tool-kit” is body size analysis, which can be used to characterise and quantify a wide range of ecological and physiological traits.… Expand
Title : CLK 2 is an oncogenic kinase and splicing regulator in breast cancer
Authors’ Affiliations: Department of Medical Oncology, and Center for Functional Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Medicine and Pathology, Harvard… Expand
WHERE THE FOSSIL RECORD FALLS FLAT: USING A BAYESIAN BIOGEOGRAPHIC MODEL TO DATE PARASITIC FLATWORM PHYLOGENIES
Amplification and overexpresssion of IKBKE activates NF-kB pathway in breast cancers.
5261 Since the successful use of kinase inhibitors in the clinical setting (e.g., Gleevec and Iressa), kinases have become an area of intense focus in the search for oncogene candidates. Based on our… Expand