Laura Mufson

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CONTEXT Adolescent depression is highly prevalent and has substantial morbidity, including suicide attempts, school dropout, and substance abuse, but many depressed adolescents are untreated. The school-based health clinic offers the potential for accessible and efficient treatment, although it is unknown whether school-based clinicians can be trained to(More)
BACKGROUND Psychotherapy is widely used for depressed adolescents, but evidence supporting its efficacy is sparse. METHODS In a controlled, 12-week, clinical trial of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), 48 clinic-referred adolescents (aged 12-18 years) who met the criteria for DSM-III-R major depressive disorder were randomly(More)
This article reviews interpersonal psychotherapy for depressed adolescents (IPT-A). IPT-A is a time-limited, evidence-based psychotherapy for depressed, nonbipolar, nonpsychotic adolescents. The article focuses on goals and phases of IPT-A, identifies problem areas and core components of treatment, and discusses specific therapeutic techniques. Efficacy(More)
OBJECTIVE To determine the independent effects of parental depression and family discord on psychopathology in offspring at high and low risk for major depression. METHOD One hundred eighty-two offspring of depressed or nondepressed parents were followed over 10 years. In direct interviews, parents' and offspring's psychopathology was evaluated by raters(More)
CONTEXT Approximately 3% of the US population receives psychotherapy each year from psychiatrists, psychologists, or social workers. A modest number of psychotherapies are evidence-based therapy (EBT) in that they have been defined in manuals and found efficacious in at least 2 controlled clinical trials with random assignment that include a control(More)
BACKGROUND Indicated interventions for adolescents with elevated depressive symptoms may help decrease rates of depression. The current study reports on the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a group indicated preventive intervention. METHODS Forty-one adolescents with elevated depression symptoms were randomized(More)
This study evaluated the efficacy of 2 programs for preventing depressive symptoms in adolescents. Participants were 380 high school students randomly assigned to a cognitive-behavioral program (CB), an interpersonal psychotherapy-adolescent skills training program (IPT-AST), or a no-intervention control. The interventions involved eight 90-min weekly(More)
OBJECTIVE High-risk studies of psychiatric disorders in parents and offspring that include 3 generations are uncommon. Multigenerational studies can be clinically useful as they can provide information for risk prediction from one generation to another for the development of empirically based interventions. Using a high-risk design, this study examines the(More)
OBJECTIVE Interpersonal psychotherapy (IPT) is effective at reducing binge episodes and inducing weight stabilization in obese adults with binge eating disorder. METHOD We piloted the administration of IPT to girls at-risk for excess weight gain (BMI 75th-97th percentile; IPT-WG) with and without loss of control (LOC) eating. Thirty-eight girls (12-17(More)
Stability of recall of DSM-III diagnoses was assessed at two interviews 2 years apart in a sample of 150 offspring, aged 6 to 23 years, at high and low risk for major depression. Stability of recall was good for major depression with the use of DSM-III criteria and fair for major depression with the use of "strict" criteria (based on 4 weeks' duration of(More)