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— During maintenance developers cannot read the entire code of large systems. They need a way to get a quick understanding of source code entities (such as, classes, methods, packages, etc.), so they can efficiently identify and then focus on the ones related to their task at hand. Sometimes reading just a method header or a class name does not tell enough(More)
Voltage-gated K+ channels (KV) and thromboxane A2 (TXA2) play critical roles in controlling pulmonary arterial tone under physiological and pathological conditions. We hypothesized that TXA2 might inhibit KV channels, thereby establishing a link between these two major pathogenic pathways in pulmonary hypertension. The TXA2 analogue U46619 inhibited IK(V)(More)
NADPH oxidase is critically involved in increased blood pressure, vascular hypertrophy, inflammation and endothelial dysfunction in experimental and clinical hypertension. We hypothesized that NADPH oxidase might also play a role in the development of spontaneous aortic tone in spontaneously hypertensive rats (SHR). Wistar Kyoto rats (WKY) were used as(More)
Neutral sphingomyelinase (nSMase)-derived ceramide has been proposed as a mediator of hypoxic pulmonary vasoconstriction (HPV), a specific response of the pulmonary circulation. Voltage-gated K(+) (K(v)) channels are modulated by numerous vasoactive factors, including hypoxia, and their inhibition has been involved in HPV. Herein, we have analyzed the(More)
Quercetin is a dietary flavonoid which exerts vasodilator, antiplatelet and antiproliferative effects and reduces blood pressure, oxidative status and end-organ damage in humans and animal models of systemic hypertension. We hypothesized that oral quercetin treatment might be protective in a rat model of pulmonary arterial hypertension. Three weeks after(More)
This paper introduces ARENA (Automatic RElease Notes generAtor), an approach for the automatic generation of release notes. ARENA extracts changes from the source code, summarizes them, and integrates them with information from versioning systems and issue trackers. It was designed based on the manual analysis of 1,000 existing release notes. To evaluate(More)
Quercetin, the most abundant dietary flavonol, exerts vasodilator, anti-hypertensive, and anti-atherogenic effects and reduces the vascular remodelling associated with elevated blood pressure. Here, we have compared the effects of quercetin in intimal- and medial-type rat vascular smooth muscle cells (VSMC) in culture. After 48 h, quercetin reduced the(More)
Object-Oriented (OO) code stereotypes are low-level patterns that reveal the design intent of a source code artifact, such as, a method or a class. They are orthogonal to the problem domain of the software and they reflect the role of a method or class from the OO problem solving point of view. However, the research community in automated reverse(More)
Many bug localization techniques rely on Text Retrieval (TR) models. The most successful approaches have been proven to be the ones combining TR techniques with static analysis, dynamic analysis, and/or software repositories information. Dynamic software analysis and software repositories mining bring a significant overhead, as they require instrumenting(More)
Text Retrieval (TR) approaches have been used to leverage the textual information contained in software artifacts to address a multitude of software engineering (SE) tasks. However, TR approaches need to be configured properly in order to lead to good results. Current approaches for automatic TR configuration in SE configure a single TR approach and then(More)