Laura Minglu Zhang

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Twelve previously untreated boys suffering from attention-deficit hyperactivity disorder (ADHD) were investigated by using proton magnetic resonance spectroscopy (1H MRS) before and after one dose (10 mg) of methylphenidate. Pre- and post-methylphenidate spectra were acquired bilaterally in the globus pallidus. Peaks of N-acetylaspartate (NAA), choline(More)
In the present study, whole-cell patch-clamp recording was used to study whether vascular endothelial growth factor (VEGF) had a regulatory effect on the potassium-channel currents. The outward delayed-rectifier potassium currents (I(K)) were recorded in acutely isolated hippocampal neurons from 14-day-old rat brains. A local application of VEGF at the(More)
The effect of rhynchophylline (Rhy) on L-type Ca2+ channel current was studied in rat ventricular myocytes using patch-clamp whole-cell recording technique. When the holding potential was -40 mV, cells were depolarized to 0 mV for 250 ms at frequency of 0.5 Hz, Rhy 10 and 50 mumol.L-1 reduced verapamil-sensitive Ca2+ inward current by 60% and 80%,(More)
The role of excitatory amino acid transporter 1 in neonatal rat neuronal damage was studied following hypoxia-ischemia. To induce hypoxia-ischemia injury, rats on postnatal day 7 were exposed to 8 % oxygen for 2 h following unilateral common carotid artery ligation. According to brain damage scoring based on Cresyl Violet staining, the neuronal damage(More)
The level of serotonin (5-HT) and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) in dorsal horn of spinal cord and periaqueductal gray (PAG) were measured using in vivo microdialysis coupled with high performance liquid chromatography and electrochemical detection. Intraplantar injection of carrageenan was used to evoke release. Extracellular(More)
The present study examined the changes of extracellular concentration of dopamine and its metabolite homovanillic acid in the striatum, the periaqueductal gray and the dorsal horn of lumbar spinal cord following intraplantar injection of carrageenan. In vivo microdialysis and high-performance liquid chromatography with electrochemical detection were(More)
Effects of rhyncophylline (Rhy) on the voltage-dependent potassium channels in isolated rat and guinea pig ventricular myocytes were studied by using patch clamp whole cell recording techniques. Rhy was found to reduce the steady-state outward current in rat ventricular myocytes when cells were depolarized from holding potential -40 mV to 0 mV. After(More)
Run-down of Ca2+ current was studied in isolated guinea pig ventricular cells and it was found to be attenuated by intracellular sodium. Calcium currents were recorded after activation of Na+ channels by a step pulse. The "run-down" in 30 min was significantly reduced compared with control cells. When NaCl (0.1-10 mM) diffused from the micropipette into the(More)
Curdlan is produced by Agrobacterium sp. ATCC 31749 under nitrogen-limited conditions not associated with cell growth. A novel curdlan production process was developed based on the different nutrient requirements for microbial cell growth and its efficiency was increased by integrating carbon/nitrogen sources control and sequencing dual fed-batch fermentors(More)
Nerve fibers containing dynorphin (Dyn) A(1-17)-like immunoreactivity were identified around cerebral arteries of guinea pig. The immunoreactive nerve fibers were richly distributed in anterior and middle cerebral arteries, but sparsely in posterior cerebral and basilar arteries. Histofluorescent study showed that large and small cerebral arteries were(More)