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Moving towards a Better Understanding of Chemotaxis
P-Rex1 Regulates Neutrophil Function
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
This work proposes that the effect of PI(3)Kgamma is through roles in the regulation of some aspects of neutrophil polarization that are relevant to movement, such as integrin-based adhesion and the accumulation of polymerized (F)-actin at the leading-edge.
PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis
This work proposes that the effect of PI(3)Kγ is through roles in the regulation of some aspects of neutrophil polarization that are relevant to movement, such as integrin-based adhesion and the accumulation of polymerized (F)-actin at the leading-edge.
Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex
Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis
It is revealed that SCs remain essential regulators of testis development long after the period of sex determination, and fetal LCs function independently from SC, germ cell or PTMC support in the prepubertal testis.
Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men
- L. O’Hara, K. McInnes, Lee B. Smith
- Biology, MedicineFASEB journal : official publication of the…
- 17 November 2014
It is concluded that autocrine androgen action within Leydig cells is essential for the lifelong support of spermatogenesis and the development and lifelong health of Leydigs cells.
KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility
The identification of KATNAL1 as an essential regulator of male fertility provides a significant novel entry point into advancing the understanding of how SC microtubule dynamics promotes male fertility.
Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing
AR-signalling is required to facilitate X-zone regression, cell clearance and to protect against adrenal degeneration during ageing, as well as being dispensable for the formation of the definitive cortex.
The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation
The results reveal an obligate requirement for the adapter protein 3BP2 in G protein-coupled receptor-mediated neutrophil function.