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BACKGROUND Although most clinical trials of coronary stents have measured nominally identical safety and effectiveness end points, differences in definitions and timing of assessment have created confusion in interpretation. METHODS AND RESULTS The Academic Research Consortium is an informal collaboration between academic research organizations in the(More)
BACKGROUND Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension. METHODS We designed a prospective, single-blind, randomized, sham-controlled trial. Patients with severe resistant hypertension were randomly assigned in a 2:1 ratio to undergo renal denervation or(More)
BACKGROUND Mitral-valve repair can be accomplished with an investigational procedure that involves the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet. METHODS We randomly assigned 279 patients with moderately severe or severe (grade 3+ or 4+) mitral regurgitation in a(More)
CONTEXT Coronary computed tomographic (CT) angiography is a noninvasive anatomic test for diagnosis of coronary stenosis that does not determine whether a stenosis causes ischemia. In contrast, fractional flow reserve (FFR) is a physiologic measure of coronary stenosis expressing the amount of coronary flow still attainable despite the presence of a(More)
Receiver-operating characteristic (ROC) analysis was originally developed during World War II to analyze classification accuracy in differentiating signal from noise in radar detection.1 Recently, the methodology has been adapted to several clinical areas heavily dependent on screening and diagnostic tests,2–4 in particular, laboratory testing,5(More)
OBJECTIVES The goal of this study was to determine the diagnostic performance of noninvasive fractional flow reserve (FFR) derived from standard acquired coronary computed tomography angiography (CTA) datasets (FFR(CT)) for the diagnosis of myocardial ischemia in patients with suspected stable coronary artery disease (CAD). BACKGROUND FFR measured during(More)
BACKGROUND The prevalence of patent foramen ovale among patients with cryptogenic stroke is higher than that in the general population. Closure with a percutaneous device is often recommended in such patients, but it is not known whether this intervention reduces the risk of recurrent stroke. METHODS We conducted a multicenter, randomized, open-label(More)
BACKGROUND Definitions of stent thrombosis that have been used in clinical trials of drug-eluting stents have been restrictive and have not been used in a uniform manner. METHODS We applied a hierarchical classification of stent thrombosis set by the Academic Research Consortium (ARC) across randomized trials involving 878 patients treated with(More)
Glenn N. Levine, MD, FACC, FAHA, Chair†; Eric R. Bates, MD, FACC, FAHA, Vice Chair*†; James C. Blankenship, MD, FACC, FSCAI, Vice Chair*‡; Steven R. Bailey, MD, FACC, FSCAI*‡; John A. Bittl, MD, FACC†§; Bojan Cercek, MD, FACC, FAHA†; Charles E. Chambers, MD, FACC, FSCAI‡; Stephen G. Ellis, MD, FACC*†; Robert A. Guyton, MD, FACC* ; Steven M. Hollenberg, MD,(More)