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Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy
Purpose: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of drug-resistant p53-null tumorsExpand
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Cancer Therapy : Preclinical Inhibition of GSK 3 B Bypass Drug Resistance of p 53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy
Purpose: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of drug-resistant p53-null tumorsExpand
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GSK3A Is Redundant with GSK3B in Modulating Drug Resistance and Chemotherapy-Induced Necroptosis
Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, are 98% identical within their kinase domain and perform similar functions in several settings;Expand
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Interaction of hydro- or lipophilic phthalocyanines with cells of different metastatic potential.
A highly metastatic (4R) and a nonmetastatic (RE4) transformed rat embryo fibroblast cell line were incubated with lipid-soluble Zn(II)-phthalocyanine (ZnPc) and its water-soluble tetrasulphonatedExpand
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Carboxyamido-Triazole Modulates Retinal Pigment Epithelial and Choroidal Endothelial Cell Attachment, Migration, Proliferation, and MMP-2 Secretion of Choroidal Endothelial Cells
Purpose: To determine the effect of the calcium signaling modulating drug carboxyamido-triazole (CAI) on substeps of exudative age-related macular degeneration (AMD) in vitro. Materials and Methods:Expand
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Immunotoxic effects of fluoride on the hemocytes of Venerupis philippinarum
The increasing levels of fluoride in the aquatic environments is a matter of concern for freshwater and marine ecosystems. Although data on fluoride toxicity to aquatic organisms are increasing inExpand
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Inferenza bayesiana per la stima del modello di bass
Associations d'un inhibiteur de tyrosine kinase de bruton (btk) et du fluorouracile pour le traitement de cancers
La presente invention concerne des therapies permettant le traitement efficace de carcinomes du colon et colorectaux. L'invention concerne une trousse pharmaceutique, comprenant des associations d'unExpand