Laura Magallanes

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Ketoprofen, a potent nonsteroidal anti-inflammatory drug, is clinically administered as a racemic mixture. One of the possible metabolism routes of ketoprofen is the inversion of the R- to S-enantiomer in the gastrointestinal tract. Ketoprofen, as a weak acid drug, might undergo recirculation through pancreatic/intestinal juices. The aim of the work was to(More)
Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representing β -oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is(More)
The objective of the current study was to examine safety and pharmacokinetic data obtained from a bioequivalence study of two brands of efavirenz carried out in healthy volunteers in order to assess the relationship between concentrations and appearance of adverse events. Drowsiness was reported in almost all the subjects 1 or 2 hours post dosing and(More)
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