Laura M Murphy

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INTRODUCTION Data regarding risk factors and clinical course of patients affected with Jervell and Lange-Nielsen syndrome (JLNS), an autosomal recessive form of the congenital long-QT syndrome (LQTS), are limited to several reported cases and a retrospective analysis. METHODS AND RESULTS We prospectively followed-up 44 JLNS patients from the U.S. portion(More)
OBJECTIVE To examine the degree to which targets for diabetes (blood pressure [BP], glycated hemoglobin [HbA1c], and low-density lipoprotein cholesterol [LDL-C]) are achieved in family practices and how these results compare with family physicians' perceptions of how well targets are being achieved. DESIGN Chart audit and physician survey. SETTING(More)
BACKGROUND Aspirin use has been associated with significant reductions in breast cancer-related mortality in some observational studies. However, these studies included women who initiated aspirin use before breast cancer diagnosis. It is unclear whether initiating aspirin use after diagnosis is associated with similar reductions in mortality. This study(More)
INTRODUCTION Breast Q questionnaire measures patient's perceptions following breast reconstruction using quality of life and satisfaction. This study assessed patient reported outcomes following mastectomy and reconstruction utilizing Breast Q. METHODS All consecutive Letterkenny Hospital patients undergoing mastectomy and breast reconstruction between(More)
Since its first performance in 1967, cardiac transplantation has emerged from a medical curiosity to become the treatment of choice for advanced heart failure. Refinements in surgical technique, development of a standardized endomyocardial biopsy grading system, and the discovery of newer immunosuppressive medications have improved the outlook for today's(More)
OBJECTIVE To assess the prevalence of prehypertension and the prevalence and treatment of hypertension in a family practice population. DESIGN Cross-sectional study. SETTING An academic family practice unit. PARTICIPANTS Practice patients aged 30 to 80 years who had visited the clinic at least once during the 2 years before the study and had at least(More)
OBJECTIVE To examine the effects of 3 different walking aids on walking capacity, temporo-spatial gait parameters, and patient satisfaction. DESIGN Observational study. SETTING University Hospital of Geneva. PARTICIPANTS Hemiparetic inpatients (N=25) with impaired gait, at an early stage of rehabilitation, unfamiliar with any of the walking aids(More)
Bone metastases occur in 65–75 % of patients with metastatic breast cancer. These patients are at risk of developing skeletal-related events (SREs). SREs are defined as any pathological fracture, spinal cord compression, hypercalcemia, and surgery or radiation required for treatment of bone metastases. Bisphosphonates are used to prevent the development of(More)
Embolic Stroke Due to Sinus of Valsalva Aneurysm Thrombus Sinus of valsalva aneurysms are rare and a prevalence of 0.09% in the general population is reported by an autopsy study. Thrombus formation in the sinus of valsalva aneurysms are a rare complication and could lead to embolic phenomena. Herein, we report a rare case of sinus of valsalva aneurysm with(More)
OBJECTIVES The aim of this study was to evaluate the influence of an approaching cancer death on end-of-life aspirin use, a frequently prescribed medication for cardiovascular disease prevention. METHODS This study was conducted using linked cancer registry and prescribing data. Breast (n=1151) and colorectal (n=1859) cancer decedents were matched to(More)